FB2024_03 , released June 25, 2024
Allele: Dmel\en3
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General Information
Symbol
Dmel\en3
Species
D. melanogaster
Name
FlyBase ID
FBal0003718
Feature type
allele
Associated gene
Dmel\en
Associated Insertion(s)
Carried in Construct
Also Known As
enLA3
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kornberg, 1981)
Progenitor genotype
Caused by aberration
T(2;3)enLA3
Cytology
Description

Break maps to approximate coordinate 33 of the inv-en region.

(Gustavson et al., 1996)

Breakpoint located 45kb upstream of the en transcription start site.

(Goldsborough and Kornberg, 1994)

Putative point mutation.

(Drees et al., 1987)

breakpoint at 25.3 to 34.2 kb

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Male en2/en3 transheterozygotes show a severe phenotype in the genitalia, which includes the absence of all internal genital organs, the entire penis apparatus, the claspers and the lateral process of the genital arch. Other viable heteroallelic combinations show a reduction or loss of these structures. Extra genital arch and anal plate bristles are sometimes seen. Female flies carrying en3 and another en mutation show variable genital abnormalities, ranging from no abnormalities, to extra or missing bristles and extra pigmentation on the eighth tergite.

      (Epper and Sanchez, 1983)

      viable

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Kornberg.

      Comments
      Comments

      en2/en3 genital discs cultured in vivo show the same phenotype as discs that are allowed to develop in situ.

      (Epper and Sanchez, 1983)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      en3
      enLA3
      (Gustavson et al., 1996, Goldsborough and Kornberg, 1994, Drees et al., 1987, Kuner et al., 1985, Poole et al., 1985, Kornberg, 1981)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)