e11 flies have an abnormal electroretinogram; they show no transient responses at light-on or light-off. e11 flies show defects when assayed in Buridan's paradigm; landmark fixation and walking appear to be close to the random level expected of blind flies or wild-type flies walking without landmarks. The walking distance of the e11 flies exceeds that of wild-type flies in this assay.
Homozygous third instar larvae are unresponsive to UVC radiation.
A large fraction of homozygotes are arrhythmic with respect to locomotor activity when kept in constant darkness at 24oC, and the average signal-to-noise ratio is lower than wild-type. Heterozygotes have intermediate SNR values between homozygotes and wild-type, indicating that their rhythmicity is not completely normal. At 20oC, most homozygotes have weak rhythmicity or are arrhythmic, at 28oC, most homozygotes have significant periodicity. Some homozygotes have extremely weak rhythms under a light-dark cycle. The eclosion rhythm is normal.
Body colour: dark. Tyrosinase formed in adults (Horowitz). Classifiable throughout larval period by dark spiracle sheaths (Brehme, 1941). Phenylthiocarbamide inhibits development of e11 homozygotes more than wild type; reverse is true for inhibition by silver chloride; heterozygotes intermediate in both cases.Mixtures of the two inhibitors affect heterozygotes to a greater extent, thus exhibiting negative heterosis (Kroman and Parsons, 1960). Under ordinary conditions, viability and fecundity of heterozygote superior to either homozygote (Moree). RK1.
e11 has abnormal neurophysiology phenotype, non-suppressible by b1
Stern, Jan. 1925.