FB2024_03 , released June 25, 2024
Allele: Dmel\e11
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General Information
Symbol
Dmel\e11
Species
D. melanogaster
Name
FlyBase ID
FBal0003280
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

e11 flies have an abnormal electroretinogram; they show no transient responses at light-on or light-off. e11 flies show defects when assayed in Buridan's paradigm; landmark fixation and walking appear to be close to the random level expected of blind flies or wild-type flies walking without landmarks. The walking distance of the e11 flies exceeds that of wild-type flies in this assay.

Homozygous third instar larvae are unresponsive to UVC radiation.

A large fraction of homozygotes are arrhythmic with respect to locomotor activity when kept in constant darkness at 24oC, and the average signal-to-noise ratio is lower than wild-type. Heterozygotes have intermediate SNR values between homozygotes and wild-type, indicating that their rhythmicity is not completely normal. At 20oC, most homozygotes have weak rhythmicity or are arrhythmic, at 28oC, most homozygotes have significant periodicity. Some homozygotes have extremely weak rhythms under a light-dark cycle. The eclosion rhythm is normal.

Body colour: dark. Tyrosinase formed in adults (Horowitz). Classifiable throughout larval period by dark spiracle sheaths (Brehme, 1941). Phenylthiocarbamide inhibits development of e11 homozygotes more than wild type; reverse is true for inhibition by silver chloride; heterozygotes intermediate in both cases.Mixtures of the two inhibitors affect heterozygotes to a greater extent, thus exhibiting negative heterosis (Kroman and Parsons, 1960). Under ordinary conditions, viability and fecundity of heterozygote superior to either homozygote (Moree). RK1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference

e11 has abnormal neurophysiology phenotype, non-suppressible by b1

Phenotype Manifest In
NOT suppressed by
Statement
Reference

e11 has retina phenotype, non-suppressible by b1

Additional Comments
Genetic Interactions
Statement
Reference

The electroretinogram phenotype of b1 ; e11 double mutant flies is identical to that of e11 single mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (56)
Notes on Origin
Discoverer

Stern, Jan. 1925.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (11)