FB2024_03 , released June 25, 2024
Allele: Dmel\Delta9K
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General Information
Symbol
Dmel\Delta9K
Species
D. melanogaster
Name
FlyBase ID
FBal0002472
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Dl9K23
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygotes with Dl6B are lethal at 29oC, imaginal discs display severe defects. The temperature sensitive period is between 25 and 2 hours before puparium formation, reduction in viability at this period is associated with developmental arrest at the pupal molt. Arrested pupae lack pigmentation, have everted eyes, antennal imaginal discs, everted legs that are inflated and wings appear as bloated sacs. Humeral macrochaetaes are deleted at high temperatures but the temperature sensitive period cannot be determined. Heat pulses immediately after pupariation causes multiplication of thoracic microchaetae, the temperature sensitive period for deletion of microchaetae overlaps and extends later in development. Scarring, eye roughening, disruption of the ommatidial array, eye glossiness and multiplication of interommatidial bristles result from heat pulses an hour after puparium formation. Defects in leg development are more severe with increasing heat pulses during the third instar. Wing venariondefects are observed with heat pulses during third instar development but a temperature sensitive period could not be determined.

Heterozygotes with Dlvi1 do not differ from Dl9K homozygotes.

Weak embryonic neurogenic phenotype.

weak allele

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Nusslein-Volhard.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)