FlyBase Allele Report: Dmel\cact[12]

General Information

Symbol

Dmel\cact¹²

Species

D. melanogaster

Name

FlyBase ID

FBal0001518

Feature type

allele

Associated gene

Dmel\cact

Associated Insertion(s)

Carried in Construct

Also Known As

cact⁰¹¹, cact^O11

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ashburner et al., 1999.10.12, Roth et al., 1991, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Roth et al., 1991)

some die during embryonic stage | recessive

(Roth et al., 1991)

Phenotype Manifest In

embryonic dorsal epidermis

(Bergmann et al., 1996, Roth et al., 1991)

filzkorper

(Bergmann et al., 1996, Geisler et al., 1992)

Detailed Description

Statement

Reference

Embryos show a ventralised phenotype of intermediate strength with expanded ventral epidermis and lacking dorsolaterally derived filzkorper. Injection of cact^ΔN25.ΔPEST or cact^ΔN50.ΔPEST RNA into the posterior end can rescue the ventralised phenotype. Injection of cact^ΔN75.ΔPEST or cact^ΔN83.ΔPEST causes a weak dorsal phenotype and injection of cact^{ΔN100.ΔPEST} or cact^{ΔN125.ΔPEST} causes complete dorsalisation.

(Bergmann et al., 1996)

Stage 2 embryos injected with cact^s.2.1 transcripts exhibit rescue of filzkorper material, rescue is not observed with injection of cact^a.2.1 transcripts.

(Geisler et al., 1992)

Moderate ventralizing phenotype: dorsal epidermis is replaced by naked epidermis of more lateral positions and sense organs of the head are lost. Expansion of twi expression in terminal regions.

(Roth et al., 1991)

Very strong cact allele.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

cact¹² has phenotype, suppressible by cact::Hsap\NFKBIA^{αTub67C.lacZ}