FB2024_03 , released June 25, 2024
Allele: Dmel\c(3)G68
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General Information
Symbol
Dmel\c(3)G68
Species
D. melanogaster
Name
FlyBase ID
FBal0001459
Feature type
allele
Associated gene
Dmel\c(3)G
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: Q78term.

(Page and Hawley, 2001)

Nucleotide substitution: C?T.

(Page and Hawley, 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:15,792,211..15,792,211 [-]
Nucleotide change:

C15792211T

Reported nucleotide change:

C?T

Amino acid change:

Q78term | c(3)G-PA; Q78term | c(3)G-PB; Q78term | c(3)G-PC

Reported amino acid change:

Q78term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Page and Hawley, 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In c(3)G68 homozygous females, pachytene oocytes show decreased X and 3rd homologous chromosome pairing, as compared to controls.

      (Billmyre et al., 2019)

      c(3)G68 females show frequent meiotic chromosome segregation errors, as assessed by X-chromosome non-disjunction.

      (Lake et al., 2019)

      Paired homologous chromosomes are only detected in 36.5% of homozygous pro-oocytes and oocytes (in contrast to wild-type cells of which 97.7% contain paired homologs).

      (Page et al., 2008)

      Females expressing c(3)GCdel.Scer\UAS.P\T.T:Zzzz\FLAG under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 in a c(3)G68 background show defects in the germ-cell nuclei; a normal synaptonemal complex is not formed.

      (Jeffress et al., 2007)

      There is a failure in homolog pairing in X/X females that are homozygous for c(3)G68.

      (Gong et al., 2005)

      Mutant females can have defects in pairing of chromosome homologs in the oocytes and in some mutant oocyte nuclei, separation of the sister chromatids appears to have occurred. Prepachytene cells in the mutant germarium and nurse cells can also show defects in chromosome homolog pairing.

      (Sherizen et al., 2005)

      When c(3)G68/c(3)G68 females are irradiated to induce double stranded breaks, 3rd chromosome crossing over is not induced.

      (Bhagat et al., 2004)

      Exchange on the X chromosome is nearly eliminated in homozygous females.

      (Page and Hawley, 2001)

      Oocytes of homozygous females lack synaptonemal complex.

      (Lindsley and Zimm, 1992)

      Effects slightly more severe than in c(3)G1. Meiotic recombination absent; first-division nondisjunction and loss high (40% for X, 2 and 3; 30% for 4). Low level of nondisjunction in second meiotic division.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      c(3)G68 is a non-suppressor of stage S1 oocyte | increased number phenotype of c(2)MEP2115

      (Joyce and McKim, 2010)
      Other
      Statement
      Reference

      c(3)G68, mei-41D18 has oocyte nucleus & meiotic cell cycle phenotype

      (McKim et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      c(3)G68; c(2)MZ0810 double mutant females exhibit crossovers at a higher than expected frequency.

      (Manheim and McKim, 2003)

      In mei-41D18; c(3)G68 oocyte nuclei premature anaphases are seen.

      (McKim et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Sandler, 1968.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (24)