FlyBase Allele Report: Dmel\Bar[M2]

General Information

Symbol

Dmel\Bar^M2

Species

D. melanogaster

Name

FlyBase ID

FBal0000846

Feature type

allele

Associated gene

Bar

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Sutton, 1943)

Progenitor genotype

Caused by aberration

In(1)Bar^M2

Cytology

Description

Distal inversion breakpoint between the B-H1 and B-H2 coding sequences.

(Kojima et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

(Sutton, 1943)

(Sutton, 1943)

(Kojima et al., 2000)

Phenotype Manifest In

eye

(Sutton, 1943)

eye | anterior

(Epps et al., 1997)

pretarsus

(Pueyo and Couso, 2004, Kojima et al., 2000)

tarsal segment 3

(Kojima et al., 2000)

tarsal segment 4

(Pueyo and Couso, 2004, Kojima et al., 2000)

Detailed Description

Statement

Reference

33% of the legs of the legs of B^M2 hemizygous males have a weak fusion between the fourth and fifth tarsal segments, with the joint not properly differentiated.

(Pueyo and Couso, 2004)

Central folding in the leg discs occurs normally in In(1)B^M2 mutants. Tarsal segments 3-5 are partially fused with each other in In(1)B^M2/Df(1)B flies.

(Kojima et al., 2000)

Homozygotes have a slight indentation at the anterior edge of the eye.

(Epps et al., 1997)

Phenotype less extreme than that of B¹. RK2A.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Bar^M2 has pretarsus phenotype, enhanceable by ap[+]/ap^UGO35

(Pueyo and Couso, 2004)

Bar^M2 has tarsal segment 4 phenotype, enhanceable by ap[+]/ap^UGO35

(Pueyo and Couso, 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The tarsal segment phenotype of B^M2 hemizygous males is enhanced by ap^UGO35/+: in the resulting flies tarsal segments 4 and 5 are shorter and are fused in 61% of the legs.

(Pueyo and Couso, 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

776

In(1)Bar^M2, v^rv Bar^M2

774

In(1)Bar^M2, In(1)f^B15, Bar^M2

Notes on Origin

Discoverer

Muller, May 1934.

Muller, 1935.

(Sutton, 1943)

Induced with: Reverse mutation of v.

Comments

Weak allele of B.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

B^M2

Bar^M2

InB^M2

(Pueyo and Couso, 2004)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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