FlyBase Allele Report: Dmel\Bar[1]

General Information

Symbol

Dmel\Bar¹

Species

D. melanogaster

Name

FlyBase ID

FBal0000817

Feature type

allele

Associated gene

Bar

Associated Insertion(s)

Carried in Construct

Also Known As

B, B¹

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Caused by aberration

Dp(1;1)Bar

Cytology

Description

B-H1 but not B-H2 is duplicated in the Dp(1;1)B duplication associated with the B¹ allele.

(Bel et al., 2011)

Insertion of a roo-element at cytological location 16A7-16A1.

(Tsubota, 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Lindsley and Zimm, 1992)

visible

(Lindsley and Zimm, 1992, Steinberg, 1937)

visible | dominant

(Brennan et al., 2001)

Phenotype Manifest In

eye

(Chauhan et al., 2012, Sedkov et al., 2003, Brennan et al., 2001, Hiebert and Birchler, 1994, Lindsley and Zimm, 1992)

ommatidium

(Lindsley and Zimm, 1992, Steinberg, 1937)

Detailed Description

Statement

Reference

B¹ flies have reduced eye size.

(Chauhan et al., 2012)

Heterozygotes have a deep anterior nick in the adult eye.

(Brennan et al., 2001)

All three pairs of legs are wild type in mutant flies. The antennae are normal.

(Mandal and Lakhotia, 1999)

B¹ males that are also mutant at mle⁴ males have narrower eyes than their mle⁴/+ sibs.

(Hiebert and Birchler, 1994)

Eye restricted to narrow vertical bar. Homozygous female fully viable. B¹/+ female has about 360 facets and shows indentation terminating in horizontal fissure on anterior margin of eye, producing a kidney-shaped eye. B¹/B¹ and B¹/+ completely separable from wild type; in some genetic backgrounds, B¹/B¹ overlaps B¹/+ slightly. Classifiable in single dose in triploids by slight anterior nick in eye; is useful in the recognition of triploids.

(Lindsley and Zimm, 1992)

RK1A. Dana\B-H1 sequences hybridized to the duplicated regions of B¹, B², B^MR2 and B^MR3.

(Tanda and Corces, 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Bar¹ has visible | dominant phenotype, enhanceable by br⁵/br[+]

(Brennan et al., 2001)

Bar¹ has visible | dominant phenotype, enhanceable by br^npr-3/br[+]

(Brennan et al., 2001)

Suppressed by

Statement

Reference

Bar¹ has visible | dominant phenotype, suppressible by br[+]/br^2Bc-1

(Brennan et al., 2001)

Bar¹ has visible | dominant phenotype, suppressible by br^rbp-5/br[+]

(Brennan et al., 2001)

Bar¹ has visible phenotype, suppressible by su(Bar)¹

(Steinberg, 1937)

Enhancer of

Statement

Reference

Bar¹ is an enhancer of visible phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

B[+]/Bar¹ is an enhancer of visible | dominant phenotype of L²

(Singh et al., 2005)

Bar¹ is an enhancer of visible phenotype of dpp^d6/dpp^d12

(Mandal and Lakhotia, 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Bar¹ has eye phenotype, enhanceable by Lpt¹

(Chauhan et al., 2012)

Bar¹, ecd¹ has eye phenotype, enhanceable by trr¹

(Sedkov et al., 2003)

Bar¹ has eye phenotype, enhanceable by br⁵/br[+]

(Brennan et al., 2001)

Bar¹ has eye phenotype, enhanceable by br^npr-3/br[+]

(Brennan et al., 2001)

Bar¹ has eye phenotype, enhanceable by oro¹/oro[+]

(Epps et al., 1997)

Bar¹ has eye phenotype, enhanceable by oro²/oro[+]

(Epps et al., 1997)

Bar¹ has phenotype, enhanceable by Bg²

Suppressed by

Statement

Reference

Bar¹ has eye phenotype, suppressible by trr^+t12

(Sedkov et al., 2003)

Bar¹ has eye phenotype, suppressible by br[+]/br^2Bc-1

(Brennan et al., 2001)

Bar¹ has eye phenotype, suppressible by br^rbp-5/br[+]

(Brennan et al., 2001)

Bar¹ has phenotype, suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Bar¹ has ommatidium phenotype, suppressible by su(Bar)¹

(Steinberg, 1937)

Bar¹ has phenotype, suppressible by mb¹

(Bonnier, 1934)

Enhancer of

Statement

Reference

Bar¹ is an enhancer of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

B[+]/Bar¹ is an enhancer of eye phenotype of L²

(Singh et al., 2005)

B[+]/Bar¹ is an enhancer of eye phenotype of dpp^d-blk

(Sedkov et al., 2003)

Bar¹ is an enhancer of antenna phenotype of dpp^d6/dpp^d12

(Mandal and Lakhotia, 1999)

Bar¹ is an enhancer of tarsal segment phenotype of dpp^d6/dpp^d12

(Mandal and Lakhotia, 1999)

Bar¹ is an enhancer of tibia phenotype of dpp^d6/dpp^d12

(Mandal and Lakhotia, 1999)

Bar¹ is an enhancer of fourth segment of antenna phenotype of dpp^d6/dpp^d12

(Mandal and Lakhotia, 1999)

Bar¹ is an enhancer of fifth segment of antenna phenotype of dpp^d6/dpp^d12

(Mandal and Lakhotia, 1999)

Bar¹ is an enhancer of arista phenotype of dpp^d6/dpp^d12

(Mandal and Lakhotia, 1999)

Bar¹ is an enhancer of femur phenotype of dpp^d6/dpp^d12

(Mandal and Lakhotia, 1999)

Bar¹ is an enhancer of leg phenotype of dpp^d6/dpp^d12

(Mandal and Lakhotia, 1999)

Bar¹ is an enhancer of male genitalia phenotype of dpp^d6/dpp^d12

(Mandal and Lakhotia, 1999)

Bar¹ is an enhancer of ommatidium phenotype of dpp^d6/dpp^d12

(Mandal and Lakhotia, 1999)

Bar¹ is an enhancer of sex comb | increased number phenotype of dpp^d6/dpp^d12

(Mandal and Lakhotia, 1999)

Bar¹ is an enhancer of phenotype of Bg²

Other

Statement

Reference

Bar¹, ecd¹ has eye phenotype

(Sedkov et al., 2003)

Bar¹, dpp^d6/dpp^d12 has third segment of antenna phenotype

(Mandal and Lakhotia, 1999)

Bar¹, dpp^d6/dpp^d12 has second segment of antenna phenotype

(Mandal and Lakhotia, 1999)

Bar¹, dpp^d6/dpp^d12 has leg sensillum phenotype

(Mandal and Lakhotia, 1999)

Bar¹, dpp^d6/dpp^d12 has antennal segment 2 sense organ phenotype

(Mandal and Lakhotia, 1999)

Bar¹, dpp^d6/dpp^d12 has antennal segment 3 sense organ phenotype

(Mandal and Lakhotia, 1999)

Bar¹, Pub¹ has eye phenotype

(Lindsley and Zimm, 1992)

Bar¹, Pub¹ has ommatidium phenotype

(Lindsley and Zimm, 1992)

Additional Comments

Genetic Interactions

Statement

Reference

Lpt¹/+ strongly enhances the reduced eye phenotype of B¹/+ flies.

(Chauhan et al., 2012)

B¹/+ ; L²/+ animals have a no eye phenotype.

(Singh et al., 2005)

In animals that are homozygous for ecd¹ and are also B¹ the addition of trr¹ enhances the eye phenotype.

(Sedkov et al., 2003)

The severity of the leg defects seen in dpp^d6/dpp^d16 flies is enhanced by B¹. There is an overall shortening in length along the proximal-distal axis of the leg and complete or partial fusion or even total loss of tarsal segments. The tibia and femur are deformed, showing shortening, bulging and disorganised bristle patterns. The coxa and trochanter are not so strongly affected. The sex comb of the prothoracic leg, when present, is always duplicated in these flies. The antenna phenotype of dpp^d6/dpp^d16 flies is enhanced by B¹; the arista, 4th and 5th segments are completely absent and the 2nd and 3rd segments are widened and deformed and have defects in the bristle pattern. B¹ ; dpp^d6/dpp^d16 flies completely lack ommatidia. All B¹ ; dpp^d6/dpp^d16 males completely lack external genitalia.

(Mandal and Lakhotia, 1999)

The B¹ eye phenotype is dominantly enhanced by oro¹ and oro². The eyes of oro¹/+ ; B¹/+ flies are approximately half the size of those of B¹/+ flies.

(Epps et al., 1997)

Interacts with B¹ to give small, glazed, almost facetless eyes.

(Lindsley and Zimm, 1992)

su(B)¹ is a recessive modifier of B¹; it causes a great increase in the number of facets in the eyes of B¹ males, and a slight increase in the number of facets in the eyes of homozygous B¹ females.

(Steinberg, 1937)

mb¹ is a recessive suppressor of B¹; it modifies B¹/B¹ females to a phenotype resembling or less severe than B¹/+ and modifies B¹/+ females to almost resemble wild type. B¹ males are modified to a phenotype resembling or less severe than Bⁱ.