FB2024_03 , released June 25, 2024
Allele: Dmel\Asx5
Open Close
General Information
Symbol
Dmel\Asx5
Species
D. melanogaster
Name
FlyBase ID
FBal0000788
Feature type
allele
Associated gene
Dmel\Asx
Associated Insertion(s)
Carried in Construct
Also Known As
AsxD1
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Gindhart and Kaufman, 1995, Simon et al., 1992)
Mutagen
ethyl methanesulfonate
(Breen and Duncan, 1986)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      denticle belt & thorax

      (Breen and Duncan, 1986)
      Detailed Description
      Statement
      Reference

      Embryos doubly mutant for PscArp.1 and Asx5 show strong posteriorly directed segmental transformations; in most embryos the thoracic ventral setal belts (VSBs) resemble typical abdominal VSBs, and from two to eight VSBs have a typical A8 shape. Many embryos have abdominal-like VSBs on the head.

      (Adler et al., 1991)

      Abdominal type denticles appear in the ventral setal belts of the thoracic segments. With respect to the degree of transformation to more posterior structures, Df(2R)trix/Df(2R)trix > Df(2R)trix/Asx5 > Asx5/Asx5, indicating that Asx5 is hypomorphic mutation. Similar genotypes derived from Df(2R)trix/Asx5 oocytes achieved by means of pole-cell transplantation display more severe transformation than their counterparts above derived from mothers carrying one dose of Asx+.

      (Breen and Duncan, 1986)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Asx5 is an enhancer of phenotype of Pc3

      (Breen and Duncan, 1986)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      recovered as suppressor of Pc

      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Duncan.

      Comments
      Comments

      Ectopic abd-A is present in parasegments 2-6 in the epidermal cells. Abd-B shows a graded expression at 9 hours along the A-P axis, more concentrated in the posterior. By 12 hours the expression is more uniform.

      (Simon et al., 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (7)