FB2024_03 , released June 25, 2024
Allele: Dmel\arm25B
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General Information
Symbol
Dmel\arm25B
Species
D. melanogaster
Name
FlyBase ID
FBal0000720
Feature type
allele
Associated gene
Dmel\arm
Associated Insertion(s)
P{}arm25B
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Cadigan and Nusse, 1996)

loss of function allele

(Peifer et al., 1991)
Mutagen
PM hybrid dysgenesis
(Peifer and Wieschaus, 1990, Riggleman et al., 1989)
Progenitor genotype
Associated Insertion(s)
P{}arm25B
Cytology
Description

P element insertion between nucleotides 3711--3953.

(Peifer and Wieschaus, 1990)

Large complex rearrangement/duplication of sequences.

(Riggleman et al., 1989)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      arm25B clones at the edge of the eye result in ectopic interommatidial bristles forming up to the edge of the eye in 95% of cases.

      (Cadigan et al., 2002)

      Homozygous clones in the eye are extremely small and only infrequently observed.

      (Wehrli and Tomlinson, 1998)

      Homozygous clones in the eye have interommatidial bristles.

      (Cadigan and Nusse, 1996)

      The cuticle phenotypes of double mutants of wghs.PN with dsh477 or arm25B are indistinguishable from the mutant germline clone phenotypes of dsh, arm and wg embryos, i.e. a lawn of denticles.

      (Noordermeer et al., 1994)

      Eggs derived from mutant germlines are laid, and have normal anterior-posterior and dorso-ventral patterning.

      (Peifer et al., 1993)

      Homozygous clones survive at a higher frequency in areas of low wg expression, dorsal regions of the leg disc. This biased distribution is produced by differential survival, not directed migration.

      (Peifer et al., 1991)

      Lesion has effects on segment polarity, head development and dorsal closure.

      (Peifer and Wieschaus, 1990)

      Mutant phenotype can be rescued to full adult viability and fertility by arm+t10.5.

      (Riggleman et al., 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      arm25B is rescued by arm+t10.5

      (Riggleman et al., 1989)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Weak arm allele.

      (Riggleman et al., 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      arm25B
      Name Synonyms
      Secondary FlyBase IDs
        References (10)