FB2024_03 , released June 25, 2024
Allele: Dmel\AdhRI-42
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General Information
Symbol
Dmel\AdhRI-42
Species
D. melanogaster
Name
FlyBase ID
FBal0000376
Feature type
allele
Associated gene
Dmel\Adh
Associated Insertion(s)
copia{}AdhRI-42
Carried in Construct
Also Known As
AdhRI42
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(Dunn and Laurie, 1995)
Progenitor genotype
Associated Insertion(s)
copia{}AdhRI-42
Cytology
Description

copia insertion 243bp 5' to the distal transcription start site.

(Brogna and Ashburner, 1997)

Insertion of a complete 5.2kb copia element within 5' sequences (at position D-248bp) between the Adh promoters and their upstream enhancer sequences.

(Dunn and Laurie, 1995)

copia insert in same orientation as the Adh gene 240 bp upstream from the start of the distal promoter.

(Strand and McDonald, 1989)

copia insertion 240 bp upstream of distal promoter. copia element insertion in 5' regulatory region.

Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
U20765
AAA88817
X15607
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      No Assay Recorded
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      (Strand and McDonald, 1989)
      Additional Information
      Statement
      Reference

      The relative level of transcripts in the AdhSL variant is 2-10 fold lower than in AdhS at all developmental stages tested except embryos where the levels are the same. The most dramatic reductions in Adh transcript levels occur in stages and tissues where copia is abundantly expressed, namely in larvae, >2 day old adults, and in fat body. AdhRI-42 transcript levels are elevated in adults in a su(wa) or a su(f) genetic background.

      (Strand and McDonald, 1989)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise deletion of the copia insertion by in vitro mutagenesis demonstrates the insertion causes the very low Adh protein levels. Excision of the copia insertion causes a three fold increase in the level of Adh protein.

      (Dunn and Laurie, 1995)
      External Crossreferences and Linkouts ( 3 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AdhRI-42
      AdhRI42
      (Brogna and Ashburner, 1997, Dunn and Laurie, 1995)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)