FB2024_03 , released June 25, 2024
Allele: Dmel\Adhfn23
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General Information
Symbol
Dmel\Adhfn23
Species
D. melanogaster
Name
FlyBase ID
FBal0000328
Feature type
allele
Associated gene
Dmel\Adh
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Martin et al., 1986)

loss of function allele

Mutagen
formaldehyde
Progenitor genotype
AdhD
Cytology
Description

CRM positive. 34 bp deletion in 3' coding region (724-758); read through of normal termination triplet.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies of the transheterozygous mutant genotypes Adhfn23/Adhn1 and Adhfn23/Adhfn6 both show the same defective phenotypic response to ethanol. These flies experience a hyperactive phase that is of a much lower magnitude than in wild type. The proportion of akinetic flies is substantially higher amongst the Adh mutants than in wild-type flies and the mutants accumulate higher amounts of ethanol. However, the mutants have a normal startle response to ethanol.

      (Wolf et al., 2002)

      Adhfn23 mutants exhibit a severely delayed recovery from ethanol exposure.

      (Singh and Heberlein, 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (31)
      Notes on Origin
      Discoverer

      Sofer.

      Comments
      Comments

      Used, carried in P-element vectors along with other Adh alleles, to study gene conversion and unequal crossing over to re-generate "Adh+". Conversion frequencies are lower between dispersed repeats than between tandem repeats.

      (Hipeau-Jacquotte et al., 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Adhfn23
      (Singh and Heberlein, 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)