FlyBase Allele Report: Dmel\ab[1]

General Information

Symbol

Dmel\ab¹

Species

D. melanogaster

Name

FlyBase ID

FBal0000067

Feature type

allele

Associated gene

Dmel\ab

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

male sterile | recessive

(Hu et al., 1995)

viable (with ab²⁶)

(Li et al., 2004)

viable (with ab^clu-1)

(Caygill and Johnston, 2008)

visible

(Bejarano et al., 2012)

visible | recessive | cold sensitive

(Thompson et al., 1988)

Phenotype Manifest In

campaniform sensillum of anterior crossvein

(Diaz-Benjumea and Garcia-Bellido, 1990)

campaniform sensillum of dorsal radius

(Hu et al., 1995, Diaz-Benjumea and Garcia-Bellido, 1990)

campaniform sensillum of dorsal radius (with ab^1D)

(Hu et al., 1995)

dorsal row of double row of wing sensilla

(Hu et al., 1995)

larval dorsal multidendritic neuron ddaE (with ab²⁶)

(Li et al., 2004)

leg

(Hu et al., 1995)

leg (with ab^1D)

(Hu et al., 1995)

macrochaeta & wing

(Hu et al., 1995)

macrochaeta & wing (with ab^1D)

(Hu et al., 1995)

male genitalia

(Hu et al., 1995)

male genitalia (with ab^1D)

(Hu et al., 1995)

mechanosensory ventral triple row bristle

(Hu et al., 1995)

medial row of triple row of wing sensilla

(Hu et al., 1995)

posterior crossvein

(Diaz-Benjumea and Garcia-Bellido, 1990)

posterior scutellar bristle

ventral row of double row of wing sensilla

(Hu et al., 1995)

wing vein (with ab^1D)

(Hu et al., 1995)

wing vein L5

(Bejarano et al., 2012, Cook et al., 2004, Hu et al., 1995, Diaz-Benjumea and Garcia-Bellido, 1990)

wing vein L5 (with ab^clu-1)

(Hu et al., 1995)

wing vein L5 | cold sensitive

(Thompson et al., 1988)

Detailed Description

Statement

Reference

Mutant show loss of distal wing vein L5.

(Bejarano et al., 2012)

Wing vein L5 is truncated distally in ab¹ flies.

(Cook et al., 2004)

ab¹/+ larvae do not exhibit a dendritic phenotype.

In ab²⁶/ab¹ mutant larvae, ddaE neurons in A5 segments have 19% more dendritic branches that the wild type.

(Li et al., 2004)

phenotype of other strong alleles is not evident in ab^clu-1. ab¹/ab^clu-1 heterozygotes show wing vein L5 failing to reach the margin of the wing. Wing vein L5 fails to reach the margin of the wing; wing veins of ab¹/ab^1D heterozygous adults are absent between the margin and the posterior crossvein. Thoracic and wing mechanosensory bristles are missing; occasionally one of the campaniform sense organs on wing vein L3 is absent; legs are gnarled and the more distal segments are reduced in length or absent; male genitalia rotated.

(Hu et al., 1995)

Removes all or some of L5, with absence of the posterior crossvein; the sensilla campaniformia of the anterior crossvein and some of the L3 are usually absent.

(Diaz-Benjumea and Garcia-Bellido, 1990)

The L5 wing vein phenotype is more severe at 20^oC than 25^oC, the temperature-sensitive period is between 10 and 15% of pupal development time.

(Thompson et al., 1988)

Vein L5 usually stops after posterior crossvein. Scutellar bristles usually fewer. Wing effect probably acts during contraction period (Waddington, cited in FBrf0020044). Overlaps wild type. RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ab¹/ab^1D is a suppressor | partially of some die during P-stage phenotype of mir-125^KO.C, mir-let7^KO.C

(Caygill and Johnston, 2008)

ab¹/ab^clu-1 is a suppressor | partially of some die during P-stage phenotype of mir-125^KO.C, mir-let7^KO.C

(Caygill and Johnston, 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

ab¹ has wing vein L5 phenotype, enhanceable by bi^omb-1/bi^omb-1

(Cook et al., 2004)

ab¹ has wing vein L5 phenotype, enhanceable by bi^omb-1/bi[+]

(Cook et al., 2004)

Enhancer of

Statement

Reference

ab¹/ab[+] is an enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

ab¹ is an enhancer of wing vein L5 phenotype of N^Ax-1

(Thompson et al., 1988)

Other

Statement

Reference

ab¹, bi^omb-1 has wing vein L5 phenotype

(Cook et al., 2004)

ab¹, bi^omb-1 has posterior crossvein phenotype

(Cook et al., 2004)

ab¹, bi^omb-1/bi[+] has wing vein L5 phenotype

(Cook et al., 2004)

ab¹/ab[+], bi^omb-1 has wing vein L5 phenotype

(Cook et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Wing vein L5 is distally truncated in the wings of ab¹/+; bi^omb-1/+ flies, but not in those of either single heterozygote. In addition, bi^omb-1/+ enhances the distal truncation of L5 seen in ab¹ homozygotes. While ab¹/ab¹ does not enhance the notching and margin bristle phenotypes of bi^omb-1 homozygotes or hemizygotes, the truncation of wing vein L5 due to ab¹/ab¹ is strongly enhanced. The posterior crossvein is also lost in these flies.

(Cook et al., 2004)

The L5 wing vein phenotype is more extreme in N^Ax-1 ab¹ double mutants, and there is a deep middorsal furrowing of the thorax (a trait characteristic of some Abruptex alleles), suggesting that ab¹ acts as an enhancer of the N^Ax-1 phenotype.

(Thompson et al., 1988)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ab¹/ab²⁶ is rescued by ab^UAS.cBa/Scer\GAL4²²¹

(Li et al., 2004)

Comments

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (2)

Bloomington

203

ab¹

Kyoto

105785

ab¹

Notes on Origin

Discoverer

Comments

Alleles fall into an allelic series with respect to wing venation and bristle defects: ab¹/ab¹ = ab⁹⁴/ab⁹⁴ < ab¹/ab^60M = ab¹/ab^G9 < ab¹/ab^1D = ab¹/ab^G5.

(Hu et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ab¹

(Simoes da Silva et al., 2019, Sugimori et al., 2016, Yalgin et al., 2015, Garaulet et al., 2014, Lee et al., 2013, Kucherenko et al., 2012, Pilgram et al., 2011, Caygill and Johnston, 2008, Christensen and Cook, 2008.4.15, Christensen and Cook, 2007.10.29, Christensen and Cook, 2006.12.5, Li et al., 2004)

abrupt¹

(Bejarano et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (20)

Report Sections

Open Close