FB2024_04 , released June 25, 2024
Allele: Scer\GAL4221
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General Information
Symbol
Scer\GAL4221
Species
S. cerevisiae
Name
FlyBase ID
FBal0328157
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
221-Gal4, Gal4221, GAL42-21, 2-21-GAL4, 2-21
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Cytology
    Description

    Mobilisation of an X-linked P{GawB} generates this line.

    Allele components
    Component
    Use(s)
    Inserted element
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    distribution deduced from reporter
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    distribution deduced from reporter (Gal4 UAS)
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    Additional Information
    Statement
    Reference

    Drives expression in class 1 dendritic arborizing neurons.

    ScerGAL4221 drives expression in class I dendritic arborizing neurons starting at embryonic stage 17; while ScerGAL498b does not begin driving expression until the first larval instar.

    ScerGAL42-21 drives expression in some neurons in the PNS including class I dendritic arborizing neurons (ddaD, ddaE and vdap) and in the longitudinal bipolar dendrite neurons (dbp). Labelling is also seen in a few cells in the brain and ventral nerve cord.

     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In

    dorsal multidendritic neuron ddaE & dendritic tree | ectopic, with shrbRNAi.UAS

    dorsal multidendritic neuron ddaF & dendritic tree | ectopic, with shrbRNAi.UAS

    Detailed Description
    Statement
    Reference

    Inhibition (using Ctet\tetXTNT-LC.UAS) of Scer\GAL4221 cells significantly reduces larval escape behavior in response to HCl application, compared to controls.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Suppressed by
    Statement
    Reference
    NOT suppressed by
    Enhancer of
    Suppressor of
    Statement
    Reference
    NOT Suppressor of
    Phenotype Manifest In
    Enhanced by
    Suppressed by
    Statement
    Reference
    NOT suppressed by
    Enhancer of
    Suppressor of
    Statement
    Reference
    NOT Suppressor of
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (7)
    References (99)