FB2024_04 , released June 25, 2024
Aberration: Dmel\Df(3L)knittrigΔ1
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General Information
Symbol
Df(3L)knittrigΔ1
Species
D. melanogaster
Name
FlyBase ID
FBab0047592
Feature type
Also Known As
knittrigΔ1, fhosΔ1
Computed Breakpoints include
Sequence coordinates
3L:8,768,907..8,768,907 (Df(3L)knittrigDelta1:bk1)
(Lammel et al., 2014)
3L:8,825,477..8,825,477 (Df(3L)knittrigDelta1:bk2)
(Lammel et al., 2014)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
P{lwB}AA142
(Lammel et al., 2014)
Mutagen
P-element activity
(Lammel et al., 2014)
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments

Imprecise excision of P{lwB}AA142 resulting in complete removal of sequences encoding Fhos isoforms PA, PB, PD, PE, PF and PG and a cluster of small genes mostly encoding predicted chitin-binding proteins.

(Lammel et al., 2014)
Comments on Cytology
Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    Df(3L)knittrigΔ1 embryos transheterozygous with Df(3L)knittrigΔ140, Df(3L)hry-i22, Df(3L)Scf-R6, Df(3L)ED4421 or Df(3L)ED4413 show reduced formation of ganglionic tracheal branches with significant penetrance - the majority of embryos show disruption in at least one ganglionic branch. No abnormal phenotype is detected for midline glial cells.

    (Lammel et al., 2014)

    Df(3L)knittrigΔ1 flies transheterozygous with Df(3L)knittrigΔ140, Df(3L)hry-i22, Df(3L)Scf-R6, Df(3L)ED4421 or Df(3L)ED4413 show reduced viability and only rare escaper flies are found. Most mutants die during pupal stages or as pharate adults. Most escapers are unable to undergo complete wing inflation, causing wrinkled wings. Some escapers show partially inflated and abnormally opaque wings. Mutant pupal wings appar normal.

    (Lammel et al., 2014)

    Inferred to overlap with: Df(3L)hry-i22.

    (Lammel et al., 2014)

    Inferred to overlap with: Df(3L)Scf-R6.

    (Lammel et al., 2014)

    Inferred to overlap with: Df(3L)ED4413.

    (Lammel et al., 2014)

    Inferred to overlap with: Df(3L)ED4421.

    (Lammel et al., 2014)

    Inferred to overlap with: Df(3L)knittrigDelta140.

    (Lammel et al., 2014)
    NOT in combination with other aberrations

    Homozygotes show reduced viability and only rare escaper flies are found. Most mutants die during pupal stages or as pharate adults. Most escapers are unable to undergo complete wing inflation, causing wrinkled wings. Some escapers show partially inflated and abnormally opaque wings. Mutant pupal wings appar normal.

    Macrophages isolated from Df(3L)knittrigΔ1 larvae show normal lamellapodia formation but display strong defects in cell flattening and spreading.

    Following a laser-induced wound in the pupal wing, macrophages in Df(3L)knittrigΔ1 mutants are still able to respond and migrate to wound sites, but their speed and direction of migration are impaired.

    (Lammel et al., 2014)
    Stocks (0)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Df(3L)knittrigΔ1
    fhosΔ1
    (Farkas et al., 2024, Shwartz et al., 2016)
    knittrigΔ1
    (Pinheiro et al., 2017, Lammel et al., 2014)
    Name Synonyms
    Secondary FlyBase IDs
      References (4)