FB2024_04 , released June 25, 2024
Aberration: Dmel\Df(3L)hry-i22
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General Information
Symbol
Df(3L)hry-i22
Species
D. melanogaster
Name
FlyBase ID
FBab0002374
Feature type
chromosomal_deletion
Also Known As
Df(3L)hi22, Df(3L)h-i22, Df(3L)hi22, Df(3R)hi22
Computed Breakpoints include

66D10;66E1-66E2

Features within 66D10--66E2
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
(Tsuda et al., 1999, Hooper et al., 1989, Ingham et al., 1985)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Deak et al., 1997, Duffy et al., 1996, Harbecke and Lengyel, 1995, Nakato et al., 1995, Pauli et al., 1995, Chorsky and Belote, 1994, Ingham et al., 1985)
Breakpoints

66D9;66E1

(Ingham et al., 1985)

66D10;66D14

(Chorsky and Belote, 1994)

66D10-66D11;66E1-66E2

(Deak et al., 1997, Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995)

66D10;66E1-66E2

(Nakato et al., 1995)
Causes alleles
dallyi22
(Tsuda et al., 1999)
hryi22
(Myat and Andrew, 2002, Abu-Issa and Cavicchi, 1996, Goto et al., 1989, Hooper et al., 1989, Fasano et al., 1988, Howard and Ingham, 1986, Ingham et al., 1985)
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << h << dally hits bk2 << l(3)s2383

Genetic mapping information
Comments

Breakpoint(s) molecularly mapped

(Ish-Horowicz et al., 1985)
Comments on Cytology

Ref: FBrf0042642.

(Nakato et al., 1995)

Left limit of break 1 from polytene analysis (FBrf0072831) Right limit of break 1 from inclusion of h (FBrf0042642) Left limit of break 2 from inclusion of dally (FBrf0110960) Right limit of break 2 from non-inclusion of dally (FBrf0110960)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
abd
(Long et al., 1996, Ingham et al., 1985)
dally
(Desbordes et al., 2005, Spradling et al., 1999, Nakato et al., 1995, BDGP Project Members, 1994-1999, Chorsky and Belote, 1994)
E(ftz)2955
(Kankel et al., 2004)
Fhos
(Lammel et al., 2014, Desbordes et al., 2005, Spradling et al., 1999, BDGP Project Members, 1994-1999)
foi
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Gug
(BDGP Project Members, 1994-1999)
hry
(Spradling et al., 1999, Abu-Issa and Cavicchi, 1996, Long et al., 1996, Harbecke and Lengyel, 1995, BDGP Project Members, 1994-1999, Macias et al., 1994, Howard and Ingham, 1986, Ingham et al., 1985)
l(3)06264
(BDGP Project Members, 1994-1999)
l(3)j5B6
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(3)S004209b
(Szeged Stock Center, 1998-)
l(3)S008418
(Szeged Stock Center, 1998-, Deak et al., 1997)
l(3)S024020a
(Szeged Stock Center, 1998-)
l(3)S048412a
(Deak et al., 1997)
l(3)S055009a
(Deak et al., 1997)
l(3)S062516b
(Deak et al., 1997)
l(3)S090001
(Szeged Stock Center, 1998-)
l(3)S110013
(Szeged Stock Center, 1998-)
mfr
(Smith, 2007)
mRpL12
(BDGP Project Members, 1994-1999)
msn
(BDGP Project Members, 1994-1999)
Prm
(Desbordes et al., 2005, Liu et al., 2003, Spradling et al., 1999, Tsuda et al., 1999, Szeged Stock Center, 1998-, Deak et al., 1997, BDGP Project Members, 1994-1999)
SrpRβ
(Ring et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)
Partially deleted / disrupted
dally
(Tsuda et al., 1999)
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    Df(3L)knittrigΔ1 embryos transheterozygous with Df(3L)hry-i22 show reduced formation of ganglionic tracheal branches with significant penetrance - the majority of embryos show disruption in at least one ganglionic branch. No abnormal phenotype is detected for midline glial cells.

    (Lammel et al., 2014)

    Df(3L)knittrigΔ1 flies transheterozygous with Df(3L)hry-i22 show reduced viability and only rare escaper flies are found. Most mutants die during pupal stages or as pharate adults. Most escapers are unable to undergo complete wing inflation, causing wrinkled wings. Some escapers show partially inflated and abnormally opaque wings. Mutant pupal wings appar normal.

    (Lammel et al., 2014)
    NOT in combination with other aberrations

    Df(3L)hry-i22 heterozygotes resist infection with wild-type group B streptococcus.

    (Baron et al., 2009)

    Tracheal patterning and lumen size is disrupted in Df(3L)hry-i22 embryos.

    (Myat et al., 2005)

    Heterozygosity for Df(3L)hry-i22 results in 0.0% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

    (Harris et al., 2003)

    Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

    (Coyne et al., 1998)

    No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.

    (Halsell and Kiehart, 1998)

    Shows no maternal enhancement of dpphr4.

    (Nicholls and Gelbart, 1998)

    Dominantly causes tergite defects in less than 50% of run3 heterozygotes.

    (Duffy et al., 1996)

    Deficient embryos show an uninterpretable mutant midgut phenotype.

    (Bilder and Scott, 1995)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Heterozygotes with Df(3L)tra display a genitalia defective phenotype, all or parts of the genital disc derivatives are missing.

    (Chorsky and Belote, 1994)

    Poor ventral cord organisation.

    (Smith et al., 1993)

    homozygous lethal

    Stocks (2)
    Notes on Origin
    Discoverer

    Belote.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (10)
    References (68)