Df(3L)449 animals rescued with P{63F/K1} stall in metamorphic development between 3 and 6 hours after puparium formation. Some mitotic larval brain cells of Df(3L)449 animals rescued with P{63F/K1} are aneuploid.
Homozygous lethal, homozygotes dies as first instar larvae. Df(3L)449 homozygotes carrying P{63F/dc} (which rescues ida and mge functions) (referred to as "e63-1dc449" animals) show only a minor reduction in viability and are fully fertile. These animals have an enlarged salivary gland lumen.