FB2024_03 , released June 25, 2024
Recombinant Construct: P{Mhc.R146N}
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General Information
Symbol
P{Mhc.R146N}
FlyBase ID
FBtp0131293
Feature type
transgenic_transposable_element
Component Allele(s)
MhcR146N
Size
Expression Data
Associated insertion(s)
0 available
Molecular map
Description and Uses
Construct components
Component allele MhcR146N
Transgenic product class
missense_variant
(Kronert et al., 2018)
Component
Use(s)
Regulatory region(s)
Mhc
Encoded product / tool
Mhc
Description

A Mhc transgene carrying an amino acid substitution equivalent to the K146N (dominant) mutation in human beta-cardiac myosin heavy chain that causes hypertrophic cardiomyopathy. (FlyBase curator comment: the mutation in the Mhc gene is given as R146N in FBrf0240086, however analysis of the release 6.32 annotated gene model indicates the change to be R147N).

(Kronert et al., 2018)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
PwMhcR146N
(Kronert et al., 2018)
P{Mhc.R146N}
(FlyBase, 1992-)
P{R146N}
(Kronert et al., 2018)
R146N
(Kronert et al., 2018)
Secondary FlyBase IDs
    References (2)