FB2024_03 , released June 25, 2024
Recombinant Construct: P{UAS-mDmd.Dp116}
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General Information
Symbol
P{UAS-mDmd.Dp116}
FlyBase ID
FBtp0092276
Feature type
transgenic_transposable_element
Component Allele(s)
Size
Expression Data
Associated insertion(s)
Molecular map
Description and Uses
Construct components
Component allele Mmus\DmdDp116.UAS
Component
Use(s)
Encoded product / tool
Description

UASt regulatory sequences drive expression of a deleted form of Mmus\Dmd which lacks the N-terminal domain and most of the rod domains (the actin-binding domains are deleted) and retains only two repeats (R23-R24) with intact cysteine-rich and C-terminal domains.

UASt regulates expression of the short C-terminal isoform (Dp116) of Mmus\Dmd (containing the first exon from the human Dp116 isoform) as described in PMID:16569668. Dp116 contains two spectrins repeats, the ww domain (dystroglycan-binding domain) and a carboxy-terminal domain involved in binding to other DGC proteins like syntrophin and dystrobrevin.

Sequence Data
Sequence (FB)
Associated Sequence Data
DNA Sequence
Extent
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Total Size
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Right end
 
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Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Secondary FlyBase IDs
    References (3)