Mehta, D.S., Zein-Sabatto, H., Ryder, P.V., Lee, J., Lerit, D.A. (2022). Drosophila centrocortin is dispensable for centriole duplication but contributes to centrosome separation. G3 (Bethesda) 12(2): jkab434.
FlyBase ID
FBrf0252569
Publication Type
Research paper
Abstract
Centrosomes are microtubule-organizing centers that duplicate exactly once to organize the bipolar mitotic spindle required for error-free mitosis. Prior work indicated that Drosophila centrocortin (cen) is required for normal centrosome separation, although a role in centriole duplication was not closely examined. Through time-lapse recordings of rapid syncytial divisions, we monitored centriole duplication and the kinetics of centrosome separation in control vs cen null embryos. Our data suggest that although cen is dispensable for centriole duplication, it contributes to centrosome separation.
