Specific sequences outside the E-box are required for proper per expression and behavioral rescue.
Lyons et al., 2000, J. Biol. Rhythms 15(6): 472--482 [
FBrf0134698]
The period E-box is sufficient to drive circadian oscillation of transcription in vivo.
Darlington et al., 2000, J. Biol. Rhythms 15(6): 462--471 [
FBrf0134697]