FB2024_02 , released April 23, 2024
Gene: Dmel\lovit
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General Information
Symbol
Dmel\lovit
Species
D. melanogaster
Name
loss of visual transmission
Annotation Symbol
CG45782
Feature Type
protein_coding_gene
FlyBase ID
FBgn0267429
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Slc45-2

Key Links
Genomic Location
Cytogenetic map
80F9-80F9
Sequence location
Recombination map
3-47
RefSeq locus
NT_037436 REGION:25236940..25670980
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables sucrose transmembrane transporter activity
inferred from sequence or structural similarity with UniProtKB:Q9VSV1
(Gene Ontology Curators, 2002-)
enables sucrose:proton symporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000751434
(GO Reference Genome Project, 2011-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in visual perception
inferred from mutant phenotype
(Xu and Wang, 2019)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in sucrose transport
inferred from sequence or structural similarity with UniProtKB:Q9VSV1
(Gene Ontology Curators, 2002-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in synaptic vesicle
inferred from direct assay
(Xu and Wang, 2019)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in membrane
inferred from biological aspect of ancestor with PANTHER:PTN000751434
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SLC45 FAMILY OF SUCROSE TRANSPORTERS -
The solute carrier family 45 (SLC45) members are H+/sucrose symporters. (Adapted from FBrf0213795 and PMID:23506898).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\lovit for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0S0WGX2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 6.02

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012)
nuclear_gene
(Drosophila Heterochromatin Genome Project, 2007)
protein_coding_gene
(Drosophila Heterochromatin Genome Project, 2007)
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
lovit-RA
FBtr0346768
NM_001316486
1967
615
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
lovit-PA
FBpp0312363
68.0
615
6.27
A0A0S0WGX2
NP_001303415
ALI30498
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lovit using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.63

Transcript Expression
microinjection
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
photoreceptor neuron
(Xu and Wang, 2016)
Additional Descriptive Data

mRNAs are enriched in photoreceptor cells (found by comparing mRNAs isolated from wild-type (w1118) heads with gl3 heads or wild-type bodies).

(Xu and Wang, 2016)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
• membrane
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in synaptic vesicle
inferred from direct assay
(Xu and Wang, 2019)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\lovit in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of lovit
Transgenic constructs containing regulatory region of lovit
Aberrations (Deficiencies and Duplications) ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (4)
Hsap\SLC45A1
9 of 14
Yes
Yes
Hsap\SLC45A2
9 of 14
Yes
No
Hsap\SLC45A4
7 of 14
No
No
Hsap\SLC45A3
3 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (4)
Rnor\Slc45a1
9 of 14
Yes
No
Rnor\Slc45a2
9 of 14
Yes
No
Rnor\Slc45a4
7 of 14
No
No
Rnor\Slc45a3
3 of 14
No
No
Mus musculus (laboratory mouse) (4)
Mmus\Slc45a1
9 of 14
Yes
No
Mmus\Slc45a2
9 of 14
Yes
Yes
Mmus\Slc45a4
7 of 14
No
No
Mmus\Slc45a3
2 of 14
No
No
Xenopus tropicalis (Western clawed frog) (9)
Xtro\slc45a2
9 of 13
Yes
Yes
Xtro\slc45a4
4 of 13
No
No
Xtro\LOC100496642
2 of 13
No
Yes
Xtro\adarb1
1 of 13
No
No
Xtro\cldn8.1
1 of 13
No
Yes
Xtro\hhat
1 of 13
No
No
Xtro\nudt16
1 of 13
No
No
Xtro\slc45a1
1 of 13
No
Yes
Xtro\slc45a3
1 of 13
No
Yes
Danio rerio (Zebrafish) (6)
Drer\slc45a2
10 of 14
Yes
No
Drer\slc45a1
9 of 14
No
No
Drer\LOC100329687
8 of 14
No
Yes
Drer\slc45a4b
8 of 14
No
No
Drer\slc45a3
3 of 14
No
No
Drer\zgc:77158
3 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (5)
Agam\AgaP_AGAP000137
10 of 12
Yes
Yes
Agam\AgaP_AGAP010854
6 of 12
No
No
Agam\AgaP_AGAP010855
6 of 12
No
No
Agam\AgaP_AGAP010856
6 of 12
No
No
Agam\AgaP_AGAP010852
3 of 12
No
No
Arabidopsis thaliana (thale-cress) (9)
Atha\SUC1
8 of 13
Yes
No
Atha\SUC2
8 of 13
Yes
No
Atha\SUC5
8 of 13
Yes
No
Atha\SUC6
8 of 13
Yes
No
Atha\SUC7
8 of 13
Yes
No
Atha\SUC8
8 of 13
Yes
No
Atha\SUC9
8 of 13
Yes
No
Atha\SUT2
8 of 13
Yes
No
Atha\SUT4
8 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\sut1
7 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:lovit. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
Slc45-1
11 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    SLC45A2; solute carrier family 45 member 2
    model of  oculocutaneous albinism type IV
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC45A1; solute carrier family 45 member 1
    9 of 14
    605763
      SLC45A2; solute carrier family 45 member 2
      9 of 14
      606202
      SLC45A4; solute carrier family 45 member 4
      7 of 14
      619581
          SLC45A3; solute carrier family 45 member 3
          3 of 14
          605097
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              esyN Network Diagram
              Interactions Browser
              MIST Molecular Interaction Search Tool
              Summary of Genetic Interactions
              esyN Network Diagram
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              External Data
              Linkouts
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              External Data
              Linkouts
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              3L
              Recombination map
              3-47
              Cytogenetic map
              80F9-80F9
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              80F9-80F9
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              Heterochromatic, cytological location not yet determined.
              (Drosophila Heterochromatin Genome Project, 2004)
              Experimentally Determined Recombination Data
              Location

              3-47

              (FlyBase, 2016)

              3-44.1

              (Comeron et al., 2012)

              3-

              (FlyBase, 1996-)
              Left of (cM)
              Right of (cM)
              Notes

              Maps to 3L heterochromatin. Map position based on localization of BcDNA:GH10292 .

              (FlyBase, 1996-)
              Stocks and Reagents
              Stocks (8)
              Genomic Clones (95)
              cDNA Clones (238)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Xu and Wang, 2019)
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  New annotation (CG41343) in release 5.2 of the genome annotation.

                  (Drosophila Heterochromatin Genome Project, 2007)

                  New annotation (CG41087) in release 3.2 of the genome annotation.

                  (Drosophila Heterochromatin Genome Project, 2004)

                  New annotation (CG40467) in release 3.2 of the genome annotation.

                  (Drosophila Heterochromatin Genome Project, 2004)
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: CG41343 CG41087 CG40467

                  (FlyBase Genome Annotators, 2014)
                  Additional comments

                  Annotations CG41343, CG41087 and CG40467 merged as CG45782 in release 6.02 of the genome annotation. This gene is no longer fragmented in the release 6 genome assembly.

                  (FlyBase Genome Annotators, 2014)

                  Sequences corresponding to " BcDNA:GH10292 " are currently dispersed in several locations in the D.melanogaster genome; the 5' end corresponds to CG41343-RB (location: 3LHet (-): 1053679..1053618, 1053550..1053373, 911745..911483), the middle portion corresponds to CG41087-RB (location: U(-): 2090079..2089732, 2089677..2089457) and the 3' end corresponds to CG40467-RB (location: 3LHet (-): 789756..789323, 789255..789081, 722703..722418).

                  (FlyBase, 1996-)
                  Nomenclature History
                  Source for database identify of

                  Source for identity of: lovit CG45782

                  (Xu and Wang, 2019)
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (9)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 22 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  References (31)