Ir, Inwardly rectifying potassium channel, Dm_3R:100326 , Dm_3R:100349
potassium inward rectifier (Kir) superfamily of channels - inward rectifiers allow a much greater K(+) influx than efflux - osmoregulation - hind gut - Malpighian tubules - regulation of spike discharge frequency and amplitude of the evoked EPSPa at the neuromuscular junction - a principal potassium conductance pathway in the salivary gland that is required for sucrose feeding
Please see the JBrowse view of Dmel\Irk1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 6.13
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Irk1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Irk1 is expressed in adult Malpighian tubules mainly in the ureter and in the principal (Type I) cells but not in the stellate (Type II) cells of the main segment and not in the initial segment.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Irk1 in JBrowse3-78
3-79.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Gene expression is increased in response to the presence of either one or two copies of Scer\GAL4hs.PB.
Source for merge of: CG13836 Ir
One or more of the processed transcripts for these genes contain several non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG46310 (FBgn0284226) and CG44159 (FBgn0265042).
Annotations CG6747 and CG13836 merged as CG44159 in release 5.47 of the genome annotation. Merge supported by second tier modENCODE junction (FBrf0217580).
Source for identity of Ir CG6747 was sequence comparison ( date:011219 ).
Source for identity of: Ir CG6747
Source for identity of: Irk1 Ir