FlyBase Gene Report: Dmel\Ir31a

General Information

Symbol

Dmel\Ir31a

Species

D. melanogaster

Name

Ionotropic receptor 31a

Annotation Symbol

CG31718

Feature Type

protein_coding_gene

FlyBase ID

FBgn0051718

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

31E1-31E1

Sequence location

2L:10,405,565..10,408,197 [+]

Recombination map

2-42

RefSeq locus

NT_033779 REGION:10405565..10408197

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables ligand-gated monoatomic ion channel activity

inferred from electronic annotation with InterPro:IPR001320

(InterPro Project Members, 2004-)

inferred from sequence model

(Benton et al., 2009)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in detection of chemical stimulus involved in sensory perception

inferred from expression pattern

(Benton et al., 2009)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR001320

(InterPro Project Members, 2004-)

inferred from sequence model

(Benton et al., 2009)

Gene Group (FlyBase)

ANTENNAL IONOTROPIC RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

ANTENNAL IONOTROPIC RECEPTORS -: Ionotropic Receptors (IR) expressed in antennal sensory neurons in Drosophila are largely thought to act as odor-responsive ion channels. IRs are a subfamily of ionotropic glutamate receptors that do not bind glutamate. Some only form functional receptors in the presence of coreceptor IRs. The profile of expression of IRs, together with broadly expressed co-receptors underlies the precise odor-responsiveness of subpopulations of antennal neurons. (Adapted from FBrf0222310).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ir31a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9PCT4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ir31a-RC

FBtr0336967

NM_001273417

2203

648

Ir31a-RD

FBtr0336968

NM_164926

2263

629

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ir31a-PC

FBpp0307910

73.7

648

7.61

FBpp0307911

71.6

629

7.65

Q8IPB8

NP_723585

AAN10751

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ir31a using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ir31a_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

neuron of antennal coeloconic sensillum ac1

(Benton et al., 2009)

Additional Descriptive Data

Ir31a transcript is expressed in the neurons of antennal coeloconic sensillum ac1. It is co-expressed with Ir75d, Ir92a and Ir76b.

(Benton et al., 2009)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Ir31a-GAL4.583}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult olfactory receptor neuron Ir31a

(Silbering et al., 2011)

antennal lobe glomerulus VL2p

(Silbering et al., 2011)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ir31a in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ir31a

View exonic expression by tissue for Dmel\Ir31a

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

318912/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051718

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051718

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051718

Flygut - An atlas of the Drosophila adult midgut

FBgn0051718

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ir31a

Transgenic constructs containing regulatory region of Ir31a

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Ir31a^f06333

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ir31a^GD14774

viable, with Scer\GAL4^Mef2.PR

Ir31a^GD14774

viable, with Scer\GAL4^pnr-MD237

Ir31a^GD14774

Sterility

Allele

fertile

Ir31a^f06333

Other Phenotypes

Allele

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ir31a^GD14774

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (17)

Hsap\GRIA1

1 of 14

Yes

Hsap\GRIA2

1 of 14

Yes

Hsap\GRIA3

1 of 14

Yes

Hsap\GRIA4

1 of 14

Yes

Hsap\GRID1

1 of 14

Yes

Hsap\GRID2

1 of 14

Yes

Hsap\GRIK1

1 of 14

Yes

Hsap\GRIK2

1 of 14

Yes

Hsap\GRIK3

1 of 14

Yes

Hsap\GRIK4

1 of 14

Yes

Hsap\GRIK5

1 of 14

Yes

Hsap\GRIN1

1 of 14

Yes

Hsap\GRIN2A

1 of 14

Yes

Hsap\GRIN2B

1 of 14

Yes

Hsap\GRIN2C

1 of 14

Yes

Hsap\GRIN2D

1 of 14

Yes

Hsap\GRIN3B

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (12)

Rnor\Gria1

1 of 14

Yes

Rnor\Gria2

1 of 14

Yes

Rnor\Gria3

1 of 14

Yes

Rnor\Gria4

1 of 14

Yes

Rnor\Grid1

1 of 14

Yes

Rnor\Grid2

1 of 14

Yes

Rnor\Grik1

1 of 14

Yes

Rnor\Grik2

1 of 14

Yes

Rnor\Grik3

1 of 14

Yes

Rnor\Grik4

1 of 14

Yes

Rnor\Grik5

1 of 14

Yes

Rnor\Grin1

1 of 14

Yes

Mus musculus (laboratory mouse) (12)

Mmus\Gria1

1 of 14

Yes

Mmus\Gria2

1 of 14

Yes

Mmus\Gria3

1 of 14

Yes

Mmus\Gria4

1 of 14

Yes

Mmus\Grid1

1 of 14

Yes

Mmus\Grid2

1 of 14

Yes

Mmus\Grik1

1 of 14

Yes

Mmus\Grik2

1 of 14

Yes

Mmus\Grik3

1 of 14

Yes

Mmus\Grik4

1 of 14

Yes

Mmus\Grik5

1 of 14

Yes

Mmus\Grin1

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (10)

Xtro\ak3

1 of 13

Yes

Xtro\dedd2

1 of 13

Yes

Xtro\grid2

1 of 13

Yes

Xtro\grik3

1 of 13

Yes

Xtro\grik4

1 of 13

Yes

Xtro\grik5-like.1

1 of 13

Yes

Xtro\grik5

1 of 13

Yes

Xtro\grin2a

1 of 13

Yes

Xtro\grin2b

1 of 13

Yes

Xtro\grin3b

1 of 13

Yes

Danio rerio (Zebrafish) (23)

Drer\gria1a

1 of 14

Yes

Drer\gria1b

1 of 14

Yes

Drer\gria2a

1 of 14

Yes

Drer\gria2b

1 of 14

Yes

Drer\gria3a

1 of 14

Yes

Drer\gria3b

1 of 14

Yes

Drer\gria4a

1 of 14

Yes

Drer\gria4b

1 of 14

Yes

Drer\grid1a

1 of 14

Yes

Drer\grid1b

1 of 14

Yes

Drer\grid2

1 of 14

Yes

Drer\grik1a

1 of 14

Yes

Drer\grik1b

1 of 14

Yes

Drer\grik2

1 of 14

Yes

Drer\grik4

1 of 14

Yes

Drer\grik5

1 of 14

Yes

Drer\grin1a

1 of 14

Yes

Drer\grin1b

1 of 14

Yes

Drer\grin3bb

1 of 14

Yes

Drer\LOC100331381

1 of 14

Yes

Drer\LOC100334689

1 of 14

Yes

Drer\si:ch211-251b21.1

1 of 14

Yes

Drer\si:dkey-183j2.10

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\glr-8

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (23)

Agam\AgaP_AGAP009014

10 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (1)

Atha\GLR2.5

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ir31a. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (73)

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0051718

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-42

Cytogenetic map

31E1-31E1

Sequence location

2L:10,405,565..10,408,197 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

31E1-31E1

Limits computationally determined from genome sequence between P{lacW}RnrL^k06709 and P{lacW}KdelR^k00311

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-42

(FlyBase, 2016)

2-35.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18963

w¹¹¹⁸; PBac{WH}Ir31a^f06333

41726

w^*; P{Ir31a-GAL4.583}235.1; TM2/TM6B, Tb¹

NIG-Fly

M2L-2368

y¹ w¹¹¹⁸; Ir31a^SK1 P{neoFRT}40A/CyO-Tb

2LG-1889

y² VhaAC39-1^cho-1 v¹; P{U6-Ir31a.NIG.sgRNA}attP40/CyO

VDRC

v100345

P{KK106002}VIE-260B

v39079

w¹¹¹⁸; P{GD14774}v39079

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (2)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0051718

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG31718) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Ir31a CG31718

(Benton et al., 2009)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

31a

(Ni, 2020)

CG31718

(National Institute of Genetics Fly Stocks, 2022-, Croset et al., 2010, Benton et al., 2009, Keleman et al., 2009.8.5, Lee et al., 2009)

DmelIR31a

(Croset et al., 2010)

IR31a

(Ni, 2020, He et al., 2019, Rimal and Lee, 2018, Hussain et al., 2016, Menuz et al., 2014, Li et al., 2013, Silbering et al., 2011, Croset et al., 2010, Marshall et al., 2010, Benton et al., 2009, Benton et al., 2009)

Ir31a

(Ali et al., 2022, Koerte et al., 2018, Ganguly et al., 2017, Grabe et al., 2016, Prieto-Godino et al., 2016, Mansourian and Stensmyr, 2015, Martin et al., 2013)

Name Synonyms

CG31718

Ionotropic receptor 31a

ionotropic receptor 31a

(Benton et al., 2009)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 27 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

318912

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PCT4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PCT4

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

318912/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051718

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051718

FlyMine - An integrated database for Drosophila genomics

FBgn0051718

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG31718

MARRVEL_MODEL - MARRVEL (model organism gene)

318912

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0051718

DRSC - Results frm RNAi screens

FBgn0051718

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ir31a_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051718

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0051718

Flygut - An atlas of the Drosophila adult midgut

FBgn0051718

References (40)

The following external sites may use different assemblies or annotations than FlyBase.

NA

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