Up-to-date information on gene product function can be found by searching UniProtKB for proteins or RNAcentral for non-coding RNAs.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dhaw\Adh using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dhaw\Adh in JBrowsePlease Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Naturally occurring tissue-specific regulatory differences for Dhaw\Adh gene are mapped to three regions within the 840bp promoter region.
Tissue specific patterns of Adh expression were studied by comparing D.melanogaster transformants that carry Adh genes from D.affinidisjuncta, D.hawaiiensis and D.grimshawi. Northern blot analysis and gel electrophoresis of transformant larvae carrying the D.affinidisjuncta and D.grimshawi Adh gene show comparable high levels of expression and broader tissue distribution of Adh expression, transformants carrying the D.hawaiiensis Adh gene show reduced levels of each.
Daff\Adh and Dhaw\Adh display markedly different levels of alcohol dehydrogenase in the larval midgut and Malpighian tubules. Comparison of the expression of Daff\Adh and Dhaw\Adh in transgenes in D.melanogaster demonstrates that the tissue specific levels of alcohol dehydrogenase are characteristic of the genes themselves. Demonstrable differences in cis-dominant regulatory information are sufficient to account for the observed regulatory variation.