FB2024_02 , released April 23, 2024
Gene: Dmel\Gapdh1
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General Information
Symbol
Dmel\Gapdh1
Species
D. melanogaster
Name
Glyceraldehyde 3 phosphate dehydrogenase 1
Annotation Symbol
CG12055
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001091
Gene Model Status
Current
Stock Availability
9 publicly available
Enzyme Name (EC)
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (1.2.1.12)
Gene Summary
Glyceraldehyde 3 phosphate dehydrogenase 1 (Gapdh1) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glycolysis, myoblast fusion and the development of somatic muscle. [Date last reviewed: 2019-09-19] (FlyBase Gene Snapshot)
All Summaries
Also Known As

GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Gapdh-1, GADPH

Key Links
Genomic Location
Cytogenetic map
43E17-43E17
Sequence location
Recombination map
2-57
RefSeq locus
NT_033778 REGION:7791901..7793380
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
inferred from genetic interaction with UniProtKB:P07487
(Sullivan et al., 1985)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
inferred from biological aspect of ancestor with PANTHER:PTN000089475
(GO Reference Genome Project, 2011-)
enables NAD binding
inferred from electronic annotation with InterPro:IPR006424, InterPro:IPR020828
(InterPro Project Members, 2004-)
enables NADP binding
inferred from electronic annotation with InterPro:IPR006424
(InterPro Project Members, 2004-)
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
(InterPro Project Members, 2004-)
enables peptidyl-cysteine S-nitrosylase activity
inferred from sequence or structural similarity with UniProtKB:P04797
(Gene Ontology Curators, 2002-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in glyceraldehyde-3-phosphate metabolic process
inferred from genetic interaction with UniProtKB:P07487
(Sullivan et al., 1985)
involved_in glycolytic process
inferred from expression pattern
(Sun et al., 1988)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in canonical glycolysis
inferred from sequence or structural similarity with UniProtKB:P16858
(Gene Ontology Curators, 2002-)
involved_in gluconeogenesis
inferred from sequence or structural similarity with UniProtKB:P16858
(Gene Ontology Curators, 2002-)
involved_in glucose metabolic process
inferred from electronic annotation with InterPro:IPR006424
(InterPro Project Members, 2004-)
involved_in glycolytic process
inferred from biological aspect of ancestor with PANTHER:PTN000089475
(GO Reference Genome Project, 2011-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in M band
inferred from direct assay
(Sullivan et al., 2003)
located_in Z disc
inferred from direct assay
(Sullivan et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000089475
(GO Reference Genome Project, 2011-)
located_in cytosol
inferred from sequence or structural similarity with UniProtKB:P16858
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (P07486)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho- glyceroyl phosphate + H(+) + NADH (1.2.1.12)
RHEA 10300:
Summaries
Gene Snapshot
Glyceraldehyde 3 phosphate dehydrogenase 1 (Gapdh1) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glycolysis, myoblast fusion and the development of somatic muscle. [Date last reviewed: 2019-09-19]
Gene Group (FlyBase)
PEPTIDYL-CYSTEINE S-NITROSYLASES -
Peptidyl-cysteine S-nitrosylases are transferases that are involved in the transfer of nitric oxide group to a sulfur atom within a cysteine residue of a protein.
GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASES -
Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in the glycolytic pathway, which is responsible for converting glucose to pyruvate with the concomitant synthesis of ATP. (Adapted from FBrf0048676.)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Gapdh1: Glyceraldehyde dehydrogenase 1
One of two genes (Gapdh1 and Gapdh2) that code for the enzyme glyceraldehyde-3-phosphate dehydrogenase [G3PD (EC.1.2.12)]. These genes are expressed in almost all cells, especially those that undergo a high rate of glycolysis.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Gapdh1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P07486)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Gapdh1-RA
FBtr0088903
NM_080369
1480
332
Gapdh1-RB
FBtr0100479
NM_001038847
1330
332
Additional Transcript Data and Comments
Reported size (kB)

1.6 (northern blot)

(Tso et al., 1985)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Gapdh1-PA
FBpp0087977
35.4
332
8.42
P07486
NP_525108
AAF59192
Gapdh1-PB
FBpp0099914
35.4
332
8.42
P07486
NP_001033936
ABC66066
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

332 aa isoforms: Gapdh1-PA, Gapdh1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Homotetramer.

(UniProt, P07486)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gapdh1 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.65

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
primordial germ cell
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval crystal cell
(Fisher et al., 2012)
dorsal pharyngeal muscle cell
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval somatic muscle cell
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
embryonic stage 15
somatic muscle cell
(Tixier et al., 2013)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
(Tso et al., 1985)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 15
muscle cell
(Tixier et al., 2013)
adult stage
flight muscle cell
(Sullivan et al., 2003)
flight muscle cell
(Sullivan et al., 2003)
flight muscle cell
• M band
(Sullivan et al., 2003)
flight muscle cell
• Z disc
(Sullivan et al., 2003)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
adult stage | female
adult hemolymph
(Zeng et al., 2016)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

Glycolytic enzymes, including Gpdh1 protein are localized to M bands and Z discs, as visualized in the isolated myofibrils of flight muscles, where immunoreactivity appears as alternating bright and less-intense bands.

(Sullivan et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in M band
inferred from direct assay
(Sullivan et al., 2003)
located_in Z disc
inferred from direct assay
(Sullivan et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gapdh1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Gapdh1
Transgenic constructs containing regulatory region of Gapdh1
Aberrations (Deficiencies and Duplications) ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (3)
Hsap\GAPDH
13 of 14
Yes
Yes
1  
Hsap\GAPDHS
7 of 14
No
Yes
1  
Hsap\PNMA8B
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (11)
Rnor\Gapdh
12 of 14
Yes
Yes
Rnor\LOC303448
10 of 14
No
Yes
Rnor\RGD1564958
10 of 14
No
Yes
Rnor\LOC108349792
9 of 14
No
Yes
Rnor\LOC108352348
9 of 14
No
Yes
Rnor\Gapdhs
7 of 14
No
Yes
Rnor\LOC120096209
5 of 14
No
Yes
Rnor\LOC102552334
4 of 14
No
Yes
Rnor\Gapdh-ps2
1 of 14
No
Yes
Rnor\Pnma8b
1 of 14
No
Yes
Rnor\RGD1564433
1 of 14
No
Yes
Mus musculus (laboratory mouse) (9)
Mmus\Gapdh
12 of 14
Yes
Yes
Mmus\Gm10358
10 of 14
No
Yes
Mmus\Gm3839
8 of 14
No
Yes
Mmus\Gapdhs
7 of 14
No
No
Mmus\Gm11214
4 of 14
No
Yes
Mmus\Gapdh-ps15
2 of 14
No
Yes
Mmus\Gm12117
2 of 14
No
Yes
Mmus\Gm15294
2 of 14
No
Yes
Mmus\Pnmal2
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\gapdh
7 of 13
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\gapdh
13 of 14
Yes
Yes
Drer\gapdhs
9 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\gpd-1
13 of 14
Yes
Yes
Cele\gpd-2
13 of 14
Yes
Yes
Cele\gpd-3
13 of 14
Yes
Yes
Cele\gpd-4
13 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP009623
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (7)
Atha\GAPC1
12 of 13
Yes
Yes
Atha\GAPCP-1
12 of 13
Yes
Yes
Atha\GAPCP-2
12 of 13
Yes
Yes
Atha\GAPC2
11 of 13
No
Yes
Atha\GAPA-2
5 of 13
No
Yes
Atha\GAPA
5 of 13
No
Yes
Atha\GAPB
5 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\TDH1
13 of 13
Yes
Yes
Scer\TDH2
13 of 13
Yes
Yes
Scer\TDH3
13 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\gpd3
12 of 12
Yes
Yes
Spom\tdh1
12 of 12
Yes
Yes
Escherichia coli (enterobacterium) (2)
Ecol\gapA
9 of 11
Yes
Yes
Ecol\epd
2 of 11
No
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Gapdh1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (2)
Gapdh2
13 of 13
CG9010
8 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GAPDH; glyceraldehyde-3-phosphate dehydrogenase
    13 of 14
    138400
         
        GAPDHS; glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
        7 of 14
        609169
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Show/hide secondary interactors 
            (data from AllianceMine provided by esyN)
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            RNA-protein
            Physical Interaction
            Assay
            References
            Gapdh1 - AGO1
            anti bait coimmunoprecipitation, quantitative reverse transcription pcr
            (Hong et al., 2009)
            Gapdh1 - Atx2
            anti bait coimmunoprecipitation, primer specific pcr
            (Zhang et al., 2013)
            protein-protein
            Physical Interaction
            Assay
            References
            Gapdh1 - AnxB10
            experimental knowledge based
            (Guruharsha et al., 2011)
            Gapdh1 - CG10638
            experimental knowledge based
            (Guruharsha et al., 2011)
            Gapdh1 - CG10887
            experimental knowledge based
            (Guruharsha et al., 2011)
            Gapdh1 - CG8353
            experimental knowledge based
            (Guruharsha et al., 2011)
            Gapdh1 - Gapdh2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Gapdh1 - Gpdh1
            two hybrid
            (Sullivan et al., 2003)
            Gapdh1 - Hsc70-2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Gapdh1 - Mdh2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Gapdh1 - RpS15Ab
            experimental knowledge based
            (Guruharsha et al., 2011)
            Gapdh1 - bs
            experimental knowledge based
            (Guruharsha et al., 2011)
            Gapdh1 - kra
            anti bait coimmunoprecipitation, Identification by mass spectrometry
            (Wang et al., 2006)
            Gapdh1 - regucalcin
            experimental knowledge based
            (Guruharsha et al., 2011)
            Gapdh1 - βTub85D
            experimental knowledge based
            (Guruharsha et al., 2011)
            Summary of Genetic Interactions
            esyN Network Diagram
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Subunit Structure (UniProtKB)
            Homotetramer.
            (UniProt, P07486 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
            KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
            External Data
            Linkouts
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2R
            Recombination map
            2-57
            Cytogenetic map
            43E17-43E17
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            43E17-43E17
            Limits computationally determined from genome sequence between P{EP}CanB2EP774 and P{lacW}lin19k01207&P{lacW}rnh1k07624
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            43E-43F
            (determined by in situ hybridisation)
            (Tso et al., 1985)
            43E-43E
            (determined by in situ hybridisation)
            (Sullivan et al., 1985)
            Experimentally Determined Recombination Data
            Location

            2-57

            (FlyBase, 2016)

            2-57.0

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (9)
            Genomic Clones (15)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (308)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Lee et al., 2010, Sullivan et al., 2003)
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  Identified with: GH12586 <up>FlyBase curator comment: EST subsequently found to be chimeric</up>.

                  (Zou et al., 2000)

                  At least a substantial fraction of three glycolytic enzymes of flight muscle cells are found colocalised at the Z-discs and M-lines, glycolytic enzyme colocalisation is interdependent. Localisation of Gapdh1, Gapdh2 and Ald at the Z-discs and M-lines requires the presence of at least Gpdh at the Z-discs and M-lines.

                  (Wojtas et al., 1997)

                  EST GH12586 is chimeric; the 5' portion (AI134984) corresponds to part of CG4461, the 3' portion (BG632702) corresponds to part of Gapdh1.

                  (FlyBase, 1996-)

                  The synergistic effects of the Adh locus, or a tightly linked locus, on the quantities of the Mdh1, Gpdh, Pgm, Idh, Men and Gapdh1 gene products in D.melanogaster derived from an African population has been determined.

                  (Li, 1992)

                  The melanogaster and takahashi subgroups of the melanogaster group have small and large subunits of Gapdh, while another 28 species (in 15 subgroups) studied were found to have only either the large or the small subunit of Gapdh.

                  (Wojtas et al., 1992)

                  Gapdh1 and Gapdh2 RNA expression has been studied.

                  (Sun et al., 1988)

                  One of two genes (Gapdh1 and Gapdh2) that code for the enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH). These genes are expressed in almost all cells, especially those that undergo a high rate of glycolysis.

                  Relationship to Other Genes
                  Source for database merge of
                  Additional comments

                  The Gapdh1 gene may have been derived from the Gapdh2 gene by retroposition.

                  (Dai et al., 2006)
                  Nomenclature History
                  Source for database identify of
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (30)
                  Reported As
                  Symbol Synonym
                  BEST:GH12586
                  CG12055
                  (National Institute of Genetics Fly Stocks, 2022-, Ibaraki et al., 2021, Chen et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, O'Keefe et al., 2011, Zhang et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Cermelli et al., 2006, Dai et al., 2006, Pile et al., 2003, Kang et al., 2002, Mount, 2001.8.14)
                  GA3PDH
                  (Luque et al., 1994)
                  GADPH
                  (Sezgin and Eanes, 2002, Mushegian et al., 1998)
                  GAP
                  (Boehm et al., 2003)
                  GAPDH
                  (Feng et al., 2022, Walls et al., 2020, Lv et al., 2019, Jeibmann et al., 2017, Kwon et al., 2015, Duboff et al., 2012, Peralta et al., 2012, Sun et al., 2011, Chang et al., 2010, Saulière et al., 2010, van der Knaap et al., 2010, Hartig et al., 2009, Pielage et al., 2008, Mendjan et al., 2006, Wang et al., 2006, Sullivan et al., 2003, Srere and Knull, 1998, Wojtas et al., 1997)
                  GAPDH I
                  (de Morais Guedes et al., 2003)
                  GAPDH-1
                  (Eeken et al., 2001)
                  GAPDH1
                  (Scaramuzzino et al., 2013, Schriner et al., 2013, Kanda et al., 2011, Carvalho et al., 2010, Hong et al., 2009)
                  GAPDHI
                  (Pinnola et al., 2007)
                  Gadph1
                  (Jia et al., 2022)
                  Gapd
                  (Matthews and Munstermann, 1994)
                  Gapdh
                  (Zhang et al., 2021, Ogneva et al., 2016, Nirala et al., 2013, Tixier et al., 2013, Thomas et al., 2012, O'Keefe et al., 2011, Lee et al., 2010, Ahrens et al., 2007, Hoeffer et al., 2003, Warren et al., 1996, Eanes, 1994)
                  Gapdh-1
                  (Lis, 1998, Rasmussen and Lis, 1995, Sun et al., 1988)
                  Gapdh1
                  (Bamgbose and Tulin, 2024, Fisher et al., 2023, Pang et al., 2023, Wong et al., 2023, Hunt and Demontis, 2022, Murakawa et al., 2022, Zhu et al., 2022, Ibaraki et al., 2021, McLaughlin et al., 2021, Zhang et al., 2021, Ceder et al., 2020, Li et al., 2020, Vásquez-Procopio et al., 2020, Genovese et al., 2019, Zhang and Zhou, 2019, Ding et al., 2018, Cogni et al., 2017, Elgart et al., 2016, Dent et al., 2015, Spratford and Kumar, 2015, Wójtowicz et al., 2015, Chen et al., 2014, dos Santos, 2014, Lavington et al., 2014, Beckett et al., 2013, Deng and Kerppola, 2013, Kwon et al., 2013, Tixier et al., 2013, Tixier et al., 2013, Eanes, 2011, Matta et al., 2011, Anholt and Williams, 2010, Barnes et al., 2010, Liu and Lehmann, 2008, Flowers et al., 2007, Muse et al., 2007, Rehwinkel et al., 2006, Walser et al., 2006, Li et al., 2003)
                  Gapdh43E
                  dmGAPDH
                  (He et al., 2013)
                  gapdh
                  (Ogneva et al., 2022, Ogneva et al., 2020, Zhang et al., 2013, Chang et al., 2010, Hartig et al., 2009, Kind and Akhtar, 2007)
                  gapdh-1
                  (Caplen et al., 2000)
                  gapdh1
                  (Dar et al., 2021, Park et al., 2018, Kim et al., 2015)
                  gh12586
                  (Zou et al., 2000)
                  Name Synonyms
                  G3-P dehydrogenase
                  (White et al., 1999)
                  GAPDH1
                  (Cho et al., 2005)
                  Glyceraldehyde 3 phosphate dehydrogenase
                  (Anholt and Williams, 2010)
                  Glyceraldehyde 3 phosphate dehydrogenase 1
                  (Cammarato et al., 2011)
                  Glyceraldehyde-3-phosphate dehydrogenase
                  (Feng et al., 2015, Zeng et al., 2015)
                  Glyceraldehyde-3-phosphate dehydrogenase1
                  (Zeng et al., 2015, Kang et al., 2002)
                  dehydrogenase
                  (Ogneva et al., 2020)
                  glyceraldehyde 3 phosphate dehydrogenase1
                  (Cermelli et al., 2006)
                  glyceraldehyde-3-phosphate
                  (Ogneva et al., 2020)
                  glyceraldehyde-3-phosphate dehydrogenase
                  (O'Keefe et al., 2011, Sun et al., 2011, Boehm et al., 2003, Sullivan et al., 2003, Sullivan et al., 1985)
                  Secondary FlyBase IDs
                  • FBgn0043822
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 58 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                  References (164)