FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: SURVIVAL MOTOR NEURON COMPLEX - GEM4B VARIANT
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General Information
Name
SURVIVAL MOTOR NEURON COMPLEX - GEM4B VARIANT
Species
D. melanogaster
Symbol
SMN-C-4B
FlyBase ID
FBgg0001831
Date last reviewed
2024-01-25
Number of members
5
Description
Description
The survival motor neuron (SMN) complex is minimally composed of SMN and Gemin proteins. The SMN complex mediates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). (Adapted from FBrf0228762).
Notes on Group

Within the melanogaster group there are differing copy numbers of the Gemin 4 gene. In the D.mel, there are three copies: Glos (Gem4a), Gem4b, Gem4c which results in the three SMN complex variant subgroups (FBrf0241402).

It was observed in D.mel that the minimal functional SMN complex is composed of only two subunits, Smn and Gem2 (FBrf0205768).

In vertebrates the SMN complex also includes the Unrip subunit.

Lanfranco et al. (FBrf0237151) suggest that Hez, Sbat and Vlet are orthologous to metazoan Gemin6, Gemin7 and Gemin8, respectively, and are components of the SMN complex. However, the data of Matera et al. (FBrf0241402) argue against this. The composition of the SURVIVAL MOTOR NEURON COMPLEX group reflects conclusions of Matera et al.

Source Material
The SURVIVAL MOTOR NEURON COMPLEX - GEM4B VARIANT Gene Group has been compiled using the following publication(s): Matera et al., 2019, Borg et al., 2015, Borg and Cauchi, 2013, and Cauchi et al., 2010 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
spliceosomal snRNP assembly
Cellular Component
SMN complex
cytoplasmic U snRNP body
Related Gene Groups
Parent group(s)
SURVIVAL MOTOR NEURON COMPLEX VARIANTS
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gem2
Gemin 2
(Matera et al., 2019, Borg et al., 2015, Borg and Cauchi, 2013, Cauchi et al., 2010)
Gem3
Gemin 3
l(3)rL562, Dhh1, dGem3
(Matera et al., 2019, Borg et al., 2015, Borg and Cauchi, 2013, Cauchi et al., 2010)
Gem4b
Gemin 4b
(Matera et al., 2019)
rig
rigor mortis
Gemin5, Gem5, l(2)05056, anon-SAGE:Wang-132
(Matera et al., 2019, Borg et al., 2015, Borg and Cauchi, 2013, Cauchi et al., 2010)
Smn
survival motor neuron
dSMN, l(3)73Ao, survival of motor neurons
(Matera et al., 2019, Borg et al., 2015, Borg and Cauchi, 2013, Cauchi et al., 2010)
External Data
Synonyms and Secondary IDs
Synonym(s)
SMN-C-4B
SURVIVAL MOTOR NEURON COMPLEX - GEM4B VARIANT
SMN-Gemin 4B complex
Secondary FlyBase ID(s)
References (5)