Cytochrome P450, or CYP genes, constitute one of the largest families of genes, with representatives in virtually all living organisms. P450 enzymes are heme-thiolate proteins best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the other to water. The CYP3 clan includes D. melanogaster CYP6, 9, 28, 308-310 and 317 family genes. Few CYP3 enzymes have been characterized, though many have been shown to metabolize xenobiotics and plant natural compounds. (Adapted from
FBrf0248421.)