FB2024_02 , released April 23, 2024
Gene Group: CYTOCHROME P450
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General Information
Name
CYTOCHROME P450
Species
D. melanogaster
Symbol
CYP450
FlyBase ID
FBgg0001222
Date last reviewed
2021-03-11
Number of members
87
Description
Description
Cytochrome P450, or CYP genes, constitute one of the largest families of genes, with representatives in virtually all living organisms. P450 enzymes are heme-thiolate proteins best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the other to water. Most animal P450s are dependent on redox partners for their supply of reducing equivalents - NADPH cytochrome P450 reductase and cytochrome b5 in microsomes; a ferredoxin and a ferredoxin reductase in mitochondria. P450 enzymes have roles in many physiological processes. Many are specialized in the metabolism of endogenous substrates (steroid hormones, lipids, etc.), but much of their notoriety has been associated with the metabolism or detoxification of xenobiotics (natural products, drugs, pesticides, etc.). In insects, they are involved in very many cases of insecticide resistance. Insect CYP genes can be assigned to 4 different phylogenetically related 'clans' named after the founding family in vertebrates (CYP3, CYP4, CYP2 clans) or their subcellular location (mitochondrial CYP clan). (Adapted from FBrf0248421.)
Notes on Group

P450s are identified by the 'Cytochrome P450' (IPR001128) InterPro signature.

Tijet et al. 2001 (FBrf0134628) originally reported that 7 D. melanogaster P450 genes are pseudogenes: Cyp6t2, Cyp6a15, Cyp9f3, Cyp6a16, spok/Cyp307a2, Cyp49a1 and Cyp313a1. Their status in the current FlyBase release (FB2021_01) is as follows: Cyp6t2Ψ and Cyp6a15Ψ) are classed as pseudogenes (not producing a protein product) - these are omitted from the CYTOCHROME P450 group; Cyp9f3 is not a pseudogene in that it produces a protein, but it contains a deletion that removes the heme-binding domain that renders it inactive as a P450 enzyme - it is omitted from this group; Cyp6a16 has a 11-bp deletion within the CDS causing a frameshift that would produce a short, non-functional protein - it is also omitted from the group; based on current gene models, the remaining three genes (spok/Cyp307a2, Cyp49a1, Cyp313a1) are predicted to encode functional P450 enzymes and these are therefore included in the CYTOCHROME P450 group. These inclusion criteria match the list of P450 genes given in FBrf0248422.

Six cytochrome P450 family members, phm (Cyp306a1), spo (Cyp307a1), spok (Cyp307a2), dib (Cyp302a1), shd (Cyp314a1) and sad (Cyp315a1) are known as 'Halloween genes' whose products are involved in the ecdysteroid biosynthetic pathway (FBrf0201926). phm, spo and spok belong to the CYP2 clan, whereas dib, shd and sad belong to the CYP MITO clan.

Source Material
The CYTOCHROME P450 Gene Group has been compiled using the following publication(s): Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, and Tijet et al., 2001 .
Key Gene Ontology (GO) terms
Molecular Function
monooxygenase activity
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
MONOOXYGENASES
Component group(s)
CYTOCHROME P450 - CYP2 CLAN
CYTOCHROME P450 - CYP3 CLAN
CYTOCHROME P450 - CYP4 CLAN
CYTOCHROME P450 - MITO CLAN
Members (87)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
CYTOCHROME P450 - CYP2 CLAN
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Cyp18a1
Cytochrome P450 18a1
Eig17-1, cyp18, P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp303a1
Cytochrome P450 303a1
l(2)35Fb, BG:DS02740.6, nompH
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp304a1
Cytochrome P450 304a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp305a1
Cytochrome P450 305a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
phtm
phantom
phm, Cyp306a1, exo, Cyp306a1-Dm
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
spo
spook
Cyp307a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
spok
spookier
Cyp307a2, Cyp307a2Ψ, Cyp307a2p, 307a2p, spook 2
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
CYTOCHROME P450 - CYP3 CLAN
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Cyp6a2
Cytochrome P450 6a2
P450, cytochrome P450, P-450-B
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6a8
Cytochrome P450 6a8
P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6a9
Cytochrome P450 6a9
P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6a13
Cytochrome P450 6a13
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6a14
Cytochrome P450 6a14
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6a17
Cytochrome P450 6a17
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6a18
Cytochrome P450 6a18
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6a19
Cytochrome P450 6a19
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6a20
Cytochrome P450 6a20
6a20
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6a21
Cytochrome P450 6a21
P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6a22
Cytochrome P450 6a22
P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6a23
Cytochrome P450 6a23
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6d2
Cytochrome P450 6d2
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6d4
Cytochrome P450 6d4
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6d5
Cytochrome P450 6d5
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6g1
Cytochrome P450 6g1
DDT-R, Rst(2)DDT, cytochrome P450, 6g1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6g2
Cytochrome P450 6g2
6g2
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6t1
Cytochrome P450 6t1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6t3
Cytochrome P450 6t3
6t3
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6u1
Cytochrome P450 6u1
6u1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6v1
Cytochrome P450 6v1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp6w1
Cytochrome P450 6w1
AntP450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp9b1
Cytochrome P450 9b1
P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp9b2
Cytochrome P450 9b2
P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp9c1
Cytochrome P450 9c1
P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp9f2
Cytochrome P450 9f2
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp9h1
Cytochrome P450 9h1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp28a5
Cytochrome P450 28a5
BG:DS00180.11
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp28c1
Cytochrome P450 28c1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp28d1
Cytochrome P450 28d1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp28d2
Cytochrome P450 28d2
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp308a1
Cytochrome P450 308a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp309a1
Cytochrome P450 309a1
309a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp309a2
Cytochrome P450 309a2
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp310a1
Cytochrome P450 310a1
anon-EST:CL1d7
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp317a1
Cytochrome P450 317a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
CYTOCHROME P450 - CYP4 CLAN
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Cyp4aa1
Cytochrome P450 4aa1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4ac1
Cytochrome P450 4ac1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4ac2
Cytochrome P450 4ac2
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4ac3
Cytochrome P450 4ac3
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4ad1
Cytochrome P450 4ad1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4ae1
Cytochrome P450 4ae1
P450, EG:152A3.6, 4ae1, TcD20
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4c3
Cytochrome P450 4c3
P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4d1
Cytochrome P450 4d1
P450, EG:87B1.1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4d2
Cytochrome P450 4d2
P450, EG:152A3.4
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4d8
Cytochrome P450 4d8
P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4d14
Cytochrome P450 4d14
EG:152A3.2
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4d20
Cytochrome P450 4d20
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4d21
Cytochrome P450 4d21
sxe1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4e1
Cytochrome P450 4e1
P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4e2
Cytochrome P450 4e2
P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4e3
Cytochrome P450 4e3
P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4g1
Cytochrome P450 4g1
T1, ASC-T1, P450, EG:165H7.1, P-450-A
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4g15
Cytochrome P450 4g15
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4p1
Cytochrome P450 4p1
P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4p2
Cytochrome P450 4p2
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4p3
Cytochrome P450 4p3
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp4s3
Cytochrome P450 4s3
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp311a1
Cytochrome P450 311a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp312a1
Cytochrome P450 312a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp313a1
Cytochrome P450 313a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp313a2
Cytochrome P450 313a2
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp313a3
Cytochrome P450 313a3
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp313a4
Cytochrome P450 313a4
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp313a5
Cytochrome P450 313a5
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp313b1
Cytochrome P450 313b1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp316a1
Cytochrome P450 316a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp318a1
Cytochrome P450 318a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
CYTOCHROME P450 - MITO CLAN
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Cyp12a4
Cytochrome P450 12a4
cytochrome P450, 12a4
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp12a5
Cytochrome P450 12a5
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp12b2
Cytochrome P450 12b2
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp12c1
Cytochrome P450 12c1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp12d1-d
Cytochrome P450 12d1 distal
Cyp12d1, Cyp12d2
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp12d1-p
Cytochrome P450 12d1 proximal
Cyp12d1, 12d1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp12e1
Cytochrome P450 12e1
12e1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp49a1
Cytochrome P450 49a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
Cyp301a1
Cytochrome P450 301a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
dib
disembodied
Cyp302a1, cytochrome P450
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
sad
shadow
Cyp315a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
shd
shade
Cyp314a1
(Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, Tijet et al., 2001)
External Data
Synonyms and Secondary IDs
Synonym(s)
CYP450
CYTOCHROMES P450
CYTOCHROME P450
Secondary FlyBase ID(s)
References (5)