FB2024_02 , released April 23, 2024
Gene Group: HELICASES
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General Information
Name
HELICASES
Species
D. melanogaster
Symbol
HEL
FlyBase ID
FBgg0001581
Date last reviewed
2020-07-08
Number of members
83
Description
Description
Helicases use the energy of ATP hydrolysis to drive the unwinding of a DNA, RNA or DNA-RNA helix. The separation of complementary strands of a nucleic-acid duplex is a fundamental requirement for many cellular metabolic processes, including transcription, recombination, replication and repair. The unwinding property of helicases depends on the type and structure of nucleic acid substrate. Thus helicases are classified as those that preferentially unwind DNA or RNA duplexes. (Adapted from PMID:21509200.)
Notes on Group

The classification of helicases within FlyBase Gene Groups largely follows that used in PMID:20456941.

Source Material
The HELICASES Gene Group has been compiled using the following publication(s): Cox et al., 2019, Costa et al., 2014, Moy et al., 2014, Costa et al., 2011, Huen et al., 2010, Ilves et al., 2010, Ulvila et al., 2010, Diop et al., 2008, Crevel et al., 2007, Moyer et al., 2006, Blanton et al., 2005, Boudet et al., 2001, Sanjuan and Marin, 2001, Bauer et al., 2000, Lasko, 2000, and Sekelsky et al., 2000 .
Key Gene Ontology (GO) terms
Molecular Function
helicase activity
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
NUCLEIC ACID CONFORMATION ISOMERASES
Component group(s)
DNA HELICASES
RNA HELICASES
Members (83)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
DEAD-BOX RNA HELICASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
abs
abstrakt
abstract
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
ais
aramis
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
bel
belle
cap, psg9, l(3)85Ac, ms(3)neo30, L3
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
BoYb
Brother of Yb
(FlyBase, 2017-)
CG5800
(FlyBase, 2017-, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
CG6418
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
CG7483
eIF4AIII, eIF4A3, l(3)84Fi, eIF4A-III, eIF4A
(FlyBase, 2017-, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
CG7878
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
CG8611
BcDNA:GH02833
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
CG9143
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
CG9630
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
CG10077
(FlyBase, 2017-, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
CG10333
DmRH19, DmPrp28
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
CG14443
(FlyBase, 2017-, Ulvila et al., 2010, Lasko, 2000)
CG32344
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
Dbp21E2
DEAD box protein 21E2
KH1
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
Dbp45A
DEAD box protein 45A
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
Dbp73D
Dead box protein 73D
DDX51
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
Dbp80
Dead box protein 80
DmDbp80
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010)
Ddx1
Dead-box-1
(FlyBase, 2017-, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
Ddx56
DEAD-box helicase 56
Hlc, A112, Helicase, 11P1, l(1)A112
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
eIF4A
eukaryotic translation initiation factor 4A
eIF-4a, l(2)gdh-4, l(2L)162, deIF4A, eukaryotic initiation factor 4A
(FlyBase, 2017-, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
Gem3
Gemin 3
l(3)rL562, Dhh1, dGem3
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
Hel25E
Helicase at 25E
UAP56, WM6, hel, jf26, l(2)gdh-12
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
mahe
maheshvara
DmRH1
(FlyBase, 2017-, Boudet et al., 2001, Lasko, 2000)
me31B
maternal expression at 31B
l(2)k06607
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
pit
pitchoune
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
Prp5
pre-mRNA processing factor 5
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
pths
porthos
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
Rm62
Rm62
Lip, Dmp68, p68
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
Rs1
Rs1
l(2)k09514, DDX27
(FlyBase, 2017-, Moy et al., 2014, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
SoYb
Sister of Yb
(FlyBase, 2017-)
vas
vasa
courgette, cgt, BG:DS00929.14
(FlyBase, 2017-, Ulvila et al., 2010, Boudet et al., 2001, Lasko, 2000)
DEAH-BOX RNA HELICASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
ath
athos
(FlyBase, 2017-, Sanjuan and Marin, 2001, Lasko, 2000)
CG1582
(FlyBase, 2017-, Sanjuan and Marin, 2001, Lasko, 2000)
CG3225
(FlyBase, 2017-, Sanjuan and Marin, 2001, Lasko, 2000)
CG8915
(FlyBase, 2017-, Sanjuan and Marin, 2001, Lasko, 2000)
CG32533
(FlyBase, 2017-, Sanjuan and Marin, 2001, Lasko, 2000)
Dhx15
DEAH-box helicase 15
(FlyBase, 2017-, Sanjuan and Marin, 2001, Lasko, 2000)
kz
kurz
EG:30B8.2, l67
(FlyBase, 2017-, Sanjuan and Marin, 2001, Lasko, 2000)
l(2)37Cb
lethal (2) 37Cb
l(2)E104, Cb
(FlyBase, 2017-, Sanjuan and Marin, 2001, Lasko, 2000)
mle
maleless
nap, napts, no-action-potential, no action potential, male lethal
(FlyBase, 2017-, Sanjuan and Marin, 2001, Lasko, 2000)
pea
peanuts
(FlyBase, 2017-, Sanjuan and Marin, 2001, Lasko, 2000)
Prp16
pre-mRNA processing factor 16
l(1)G0007, lethal (1) G0007, l(1)G0103, l(1)G0028, l(1)G0476
(FlyBase, 2017-, Sanjuan and Marin, 2001, Lasko, 2000)
Rhau
RHAU helicase
38E.15
(FlyBase, 2017-, Sanjuan and Marin, 2001, Lasko, 2000)
spn-E
spindle E
hls, spnE, homeless, fs(1)hls
(FlyBase, 2017-, Sanjuan and Marin, 2001, Lasko, 2000)
MCM2-7 COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
dpa
disc proliferation abnormal
Mcm4, DmMCM4, l(2)43Ca
(FlyBase, 2017-, Costa et al., 2014, Costa et al., 2011, Ilves et al., 2010, Crevel et al., 2007, Moyer et al., 2006, Blanton et al., 2005)
Mcm2
Minichromosome maintenance 2
DmMCM2, MCM2-7
(FlyBase, 2017-, Costa et al., 2014, Costa et al., 2011, Ilves et al., 2010, Crevel et al., 2007, Moyer et al., 2006, Blanton et al., 2005)
Mcm3
Minichromosome maintenance 3
small mushroom bodies, smu, DmMCM3, PCR2
(FlyBase, 2017-, Costa et al., 2014, Costa et al., 2011, Ilves et al., 2010, Crevel et al., 2007, Moyer et al., 2006, Blanton et al., 2005)
Mcm5
Minichromosome maintenance 5
DmMCM5
(FlyBase, 2017-, Costa et al., 2014, Costa et al., 2011, Ilves et al., 2010, Crevel et al., 2007, Moyer et al., 2006, Blanton et al., 2005)
Mcm6
Minichromosome maintenance 6
fs(1)K1214, DmMCM6
(FlyBase, 2017-, Costa et al., 2014, Costa et al., 2011, Ilves et al., 2010, Crevel et al., 2007, Moyer et al., 2006, Blanton et al., 2005)
Mcm7
Minichromosome maintenance 7
DmMCM7
(FlyBase, 2017-, Costa et al., 2014, Costa et al., 2011, Ilves et al., 2010, Crevel et al., 2007, Moyer et al., 2006, Blanton et al., 2005)
MCM8/9 HELICASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
rec
recombination-defective
MCM8
(FlyBase, 2017-, Crevel et al., 2007, Blanton et al., 2005)
RAD3/XPD-LIKE DNA HELICASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG11403
EG:33C11.2
(FlyBase, 2017-)
Rtel1
Regulator of telomere elongation helicase 1
(FlyBase, 2017-)
Xpd
Xeroderma pigmentosum D
DmXPD, ERCC2, l(2)SH2137
(FlyBase, 2017-)
RECQ-LIKE DNA HELICASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Blm
Bloom syndrome helicase
mus309, DmBlm, Ku70, Bloom syndrome helicase ortholog, gesta1
(Cox et al., 2019, FlyBase, 2017-, Lasko, 2000, Sekelsky et al., 2000)
RecQ4
RecQ4 helicase
(Cox et al., 2019, FlyBase, 2017-, Lasko, 2000, Sekelsky et al., 2000)
RecQ5
RecQ5 helicase
RECQE, Q1, DQ1, RECQ5/QE
(Cox et al., 2019, FlyBase, 2017-, Lasko, 2000, Sekelsky et al., 2000)
RUVB-LIKE DNA HELICASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
pont
pontin
dPontin, RUVBL1, Tip49, Tip49/Pontin
(FlyBase, 2017-, Huen et al., 2010, Diop et al., 2008, Bauer et al., 2000)
rept
reptin
dReptin, l(3)06945, Tip48, Tip48/Reptin, psg10
(FlyBase, 2017-, Huen et al., 2010, Diop et al., 2008, Bauer et al., 2000)
SKI2-LIKE RNA HELICASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Brr2
Brr2 U5 snRNP complex subunit
l(3)72Ab
(FlyBase, 2017-, Lasko, 2000)
Mtr4
Mtr4 helicase
l(2)35Df, l(2)br44, l(2)k14423, dMtr4, BG:DS09217.2
(FlyBase, 2017-, Lasko, 2000)
tst
twister
Ski2
(FlyBase, 2017-, Lasko, 2000)
UNCLASSIFIED DNA HELICASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Dna2
DNA replication helicase/nuclease 2
mus-109, mus109, mus(1)109
(FlyBase, 2017-)
Fancm
Fanconi anemia group M helicase
(FlyBase, 2017-)
hay
haywire
ERCC3, XPB, TFIIH, DmXPB, nc2
(FlyBase, 2017-)
Irbp
Inverted repeat-binding protein
Ku70, YPF1, DmKu70, Ku, YPF1β
(FlyBase, 2017-)
mle
maleless
nap, napts, no-action-potential, no action potential, male lethal
(FlyBase, 2017-)
mtDNA-helicase
mitochondrial DNA helicase
mtDNA helicase, d-mtDNA helicase, Twinkle
(FlyBase, 2017-)
mus301
mutagen-sensitive 301
spn-C, spnC, spindle-C
(FlyBase, 2017-, Lasko, 2000)
obe
obelus
(FlyBase, 2017-)
Pif1
Pif1 DNA helicase
(FlyBase, 2017-)
PolQ
DNA polymerase theta
mus308, mutagen-sensitive 308, Pol θ
(FlyBase, 2017-)
Rhau
RHAU helicase
38E.15
(FlyBase, 2017-)
rin
rasputin
Nts, Next to squid, rasp
(FlyBase, 2017-)
Suv3
Suv3 helicase
dmsuv3
(FlyBase, 2017-)
Upf1
Upf1 RNA helicase
(FlyBase, 2017-)
UNCLASSIFIED RNA HELICASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
rin
rasputin
Nts, Next to squid, rasp
(FlyBase, 2017-)
Suv3
Suv3 helicase
dmsuv3
(FlyBase, 2017-)
UPF1-LIKE RNA HELICASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
armi
armitage
(FlyBase, 2017-)
CG6204
(FlyBase, 2017-)
CG6701
(FlyBase, 2017-)
Helz
Helicase with zinc finger
(FlyBase, 2017-)
Mov10
Mov10 RISC complex RNA helicase
(FlyBase, 2017-)
salsa
salsa
(FlyBase, 2017-)
Setx
Senataxin
(FlyBase, 2017-)
Upf1
Upf1 RNA helicase
(FlyBase, 2017-)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
HEL
HELICASES
Secondary FlyBase ID(s)
References (18)