FB2024_03 , released June 25, 2024
Gene Group: CORE 1 BETA 1,3-GALACTOSYLTRANSFERASES
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General Information
Name
CORE 1 BETA 1,3-GALACTOSYLTRANSFERASES
Species
D. melanogaster
Symbol
C1GALT
FlyBase ID
FBgg0001320
Date last reviewed
2020-02-03
Number of members
11
Description
Description
Core 1 3-beta-galactosyltransferases elongate O-linked N-acetylgalactosamine (O-GalNAc) by adding galactose in a β1,3 linkage, thereby building the 'T-antigen' or 'core-1' structure. In contrast to mammals, D. melanogaster has several such enzymes, each expressed in distinct patterns. (Adapted from FBrf0207265.)
Notes on Group

CG2983 shares a high degree of overall sequence similarity with the other putative core 1 GalTs, but appears to lack critical amino acids within the most highly conserved sequence motifs (FBrf0207265).

Source Material
The CORE 1 BETA 1,3-GALACTOSYLTRANSFERASES Gene Group has been compiled using the following publication(s): Yamamoto-Hino et al., 2015, Lin et al., 2008, and Müller et al., 2005 .
Key Gene Ontology (GO) terms
Molecular Function
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity
Biological Process
O-glycan processing, core 1
Cellular Component
Enzymatic activity
Enzyme name (EC)
N-acetylgalactosaminide beta-1,3-galactosyltransferase (2.4.1.122)
Related Gene Groups
Parent group(s)
GALACTOSYLTRANSFERASES
Members (11)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
C1GalTA
Core 1 Galactosyltransferase A
dC1GalT1, C1GalT1, core 1 β1,3-galactosyltransferase
(FlyBase, 2017-, Yamamoto-Hino et al., 2015, Lin et al., 2008, Müller et al., 2005)
CG2975
(FlyBase, 2017-, Yamamoto-Hino et al., 2015, Lin et al., 2008, Müller et al., 2005)
CG2983
(FlyBase, 2017-, Yamamoto-Hino et al., 2015, Lin et al., 2008)
CG3119
(FlyBase, 2017-, Yamamoto-Hino et al., 2015, Lin et al., 2008)
CG8708
dC1GalT2
(FlyBase, 2017-, Yamamoto-Hino et al., 2015, Lin et al., 2008, Müller et al., 2005)
CG18558
(FlyBase, 2017-, Yamamoto-Hino et al., 2015, Lin et al., 2008)
CG34056
(FlyBase, 2017-, Yamamoto-Hino et al., 2015, Lin et al., 2008, Müller et al., 2005)
CG34057
(FlyBase, 2017-, Yamamoto-Hino et al., 2015, Lin et al., 2008, Müller et al., 2005)
CG34451
(FlyBase, 2017-)
CG34452
(FlyBase, 2017-)
tgy
twiggy
(FlyBase, 2017-, Yamamoto-Hino et al., 2015, Lin et al., 2008)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
C1GALT
CORE 1 BETA 1,3-GALACTOSYLTRANSFERASES
Secondary FlyBase ID(s)
References (5)