FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: TORC2 COMPLEX
Open Close
General Information
Name
TORC2 COMPLEX
Species
D. melanogaster
Symbol
TORC2
FlyBase ID
FBgg0000908
Date last reviewed
2023-08-08
Number of members
4
Description
Description
TOR complex 2 (TORC2) is a target of rapamycin (Tor) kinase-containing complex that phosphorylates several AGC family kinases, including Akt1 (PKB). mTORC2 regulates a variety of cellular processes such as insulin signaling and actin reorganization. It is insensitive to rapamycin. (Adapted from FBrf0238220).
Notes on Group
Source Material
The TORC2 COMPLEX Gene Group has been compiled using the following publication(s): Takahara and Maeda, 2013 and Yang et al., 2006 .
Key Gene Ontology (GO) terms
Molecular Function
protein serine/threonine kinase activity
Biological Process
protein phosphorylation
Cellular Component
TORC2 complex
Enzymatic activity
Enzyme name (EC)
non-specific serine/threonine protein kinase (2.7.11.1)
Related Gene Groups
Parent group(s)
TOR COMPLEXES
Other related group(s)
Positive Regulators of Insulin-like Receptor Signaling Pathway
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Lst8
Lst8
dLST8, dGβL
(Takahara and Maeda, 2013, Yang et al., 2006)
mTor
mechanistic Target of rapamycin
Tor, dTOR, target of rapamycin, TORC1, target-of-rapamycin
(Takahara and Maeda, 2013, Yang et al., 2006)
rictor
rapamycin-insensitive companion of Tor
dRictor
(Takahara and Maeda, 2013, Yang et al., 2006)
Sin1
SAPK-interacting protein 1
dSin1
(Takahara and Maeda, 2013, Yang et al., 2006)
External Data
Synonyms and Secondary IDs
Synonym(s)
TORC2
TORC2 COMPLEX
Tor Complex 2
mTORC2
TOR-C2
Secondary FlyBase ID(s)
References (3)