FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: WNT ENHANCEOSOME
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General Information
Name
WNT ENHANCEOSOME
Species
D. melanogaster
Symbol
WNT-E
FlyBase ID
FBgg0000895
Date last reviewed
2023-09-28
Number of members
6
Description
Description
The Wnt enhanceosome complex binds to Wnt/wg-enhancer elements via the TCF/LEF protein, pan. In the absence nuclear β-catenin (arm), Wnt/wg-responsive genes are silenced by the repressor gro binding to the enhanceosome. Activation of the canonical Wnt signaling pathway leads to arm accumulation in the nucleus, incorporation into the enhanceosome and the stimulation of transcription. (Adapted from FBrf0235074 and FBrf0229654).
Notes on Group

Wnt enhanceosome components are shown for the canonical Wnt signaling activated form.

Source Material
The WNT ENHANCEOSOME Gene Group has been compiled using the following publication(s): van Tienen et al., 2017 and Fiedler et al., 2015 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
canonical Wnt signaling pathway
positive regulation of transcription by RNA polymerase II
Cellular Component
beta-catenin-TCF complex
Related Gene Groups
Other related group(s)
Wnt-TCF Signaling Pathway Core Components
Members (6)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
arm
armadillo
β-catenin, β-cat, beta-catenin, b-catenin, βcatenin
(van Tienen et al., 2017)
Chi
Chip
Ldb, dLdb
(van Tienen et al., 2017, Fiedler et al., 2015)
lgs
legless
BCL9
(van Tienen et al., 2017)
pan
pangolin
dTCF, TCF, l(4)13, T cell factor, LEF-1
(van Tienen et al., 2017)
pygo
pygopus
gam, BEST:LD21971, dPygo
(van Tienen et al., 2017)
Ssdp
Sequence-specific single-stranded DNA-binding protein
l(3)neo48
(Fiedler et al., 2015)
External Data
Synonyms and Secondary IDs
Synonym(s)
WNT-E
WNT ENHANCEOSOME
β-catenin-TCF complex
Secondary FlyBase ID(s)
References (3)