FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: SCF-SLMB UBIQUITIN LIGASE COMPLEX
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General Information
Name
SCF-SLMB UBIQUITIN LIGASE COMPLEX
Species
D. melanogaster
Symbol
SCF-SLMB
FlyBase ID
FBgg0000894
Date last reviewed
2023-08-08
Number of members
4
Description
Description
SCF-slmb ubiquitin ligase complex ubiquitinates proteins, targeting them for degradation by the proteasome. (FBrf0217546).
Notes on Group

The SCF-slmb ubiquitin ligase complex has been shown to play a key role in the negative regulation of the canonical Wnt, Hedgehog (FBrf0214241) and insulin-like receptor (FBrf0222810) pathways.

Source Material
The SCF-SLMB UBIQUITIN LIGASE COMPLEX Gene Group has been compiled using the following publication(s): Wong et al., 2013 and Roberts et al., 2012 .
Key Gene Ontology (GO) terms
Molecular Function
ubiquitin protein ligase activity
Biological Process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
SCF ubiquitin ligase complex
Related Gene Groups
Other related group(s)
Negative Regulators of Wnt-TCF Signaling Pathway
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Cul1
Cullin 1
lin19, Cul-1, dCul1, l(2)k01207, lin19-like
(Wong et al., 2013, Roberts et al., 2012)
Roc1a
Regulator of cullins 1a
Rbx1, EG:115C2.11, dRbx1, ROC1
(Wong et al., 2013, Roberts et al., 2012)
SkpA
SKP1-related A
Skp1, dSkpA, l(1)G0037, EG:115C2.4, Skp
(Wong et al., 2013, Roberts et al., 2012)
slmb
supernumerary limbs
slimb, shiva, ica, shv, icare
(Wong et al., 2013, Roberts et al., 2012)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
SCF-SLMB
SCF-SLMB UBIQUITIN LIGASE COMPLEX
Slimb-βTrCP-SCF complex
SkpA-Cul1-slmb-Roc1a E3 ligase complex
Cullin1/Roc1a/SkpA/Slimb E3 ligase
Secondary FlyBase ID(s)
References (3)