Gene Group - Macromolecular Complex: N-TERMINAL ACETYLTRANSFERASE C COMPLEX

General Information

Name

N-TERMINAL ACETYLTRANSFERASE C COMPLEX

Species

D. melanogaster

Symbol

NATC

FlyBase ID

FBgg0000653

Date last reviewed

2024-01-25

Number of members

Description

The N-terminal acetyltransferase C (NatC) complex catalyzes the acetylation of the N-terminal methionine of polypeptides with Met-Leu-, Met-Phe-, Met-Ile- and Met-Trp- N termini. (Adapted from PMID:19660096, PMID:22405572 and FBrf0234437).

Notes on Group

Naa30A and Naa30B are both catalytic subunit isoforms for the NatC complex (FBrf0234437, FBrf0194437). High-throughput expression studies indicate that Naa30A is ubiquitously expressed and Naa30B tends to be more testis-specific.

Based Complex Portal (EMBL-EBI) curation, Sbat, ortholgous to human NatC complex auxiliary subunit NAA38, has been included in the N-TERMINAL ACETYLTRANSFERASE C COMPLEX gene group.

Source Material

The N-TERMINAL ACETYLTRANSFERASE C COMPLEX Gene Group has been compiled using the following publication(s): Matera et al., 2019 and Rathore et al., 2016 .

Key Gene Ontology (GO) terms

Molecular Function

peptide alpha-N-acetyltransferase activity

Biological Process

N-terminal protein amino acid acetylation

Cellular Component

NatC complex

Enzymatic activity

Enzyme name (EC)

N-terminal amino-acid N(alpha)-acetyltransferase NatA (2.3.1.255)

Related Gene Groups

Parent group(s)