FB2024_03 , released June 25, 2024
Gene Group: NON-INHIBITORY SERPINS
Open Close
General Information
Name
NON-INHIBITORY SERPINS
Species
D. melanogaster
Symbol
N-SPN
FlyBase ID
FBgg0000126
Date last reviewed
2013-02-15
Number of members
13
Description
Description
The serpin family is a structurally-related group of secreted proteins containing the serpin-fold, a 350-400 amino acid domain. The non-inhibitory serpins (SERine Protease INhibitors) lack the key proteinase cleavage site required to target proteases. The non-inhibitory serpins have diverse roles and in D.mel, many are uncharacterised. (Adapted from FBrf0213937 & FBrf0209216).
Notes on Group

The list of NON-INHIBITORY SERPINS is taken from Table I, FBrf0209216. They are predicted to lack protease inhibitory actively due to the lack of the proteinase cleavage site.

CG43366 encodes a large (2140 amino acid) protein with a C-terminal block of 350 amino acids with homology to the serpin core. FBrf0213937 states that "to the best of our knowledge, this is the only example of a serpin-related fold that is incorporated into a large protein".

Source Material
The NON-INHIBITORY SERPINS Gene Group has been compiled using the following publication(s): Gubb, 2012.9.27, Reichhart et al., 2011, and Garrett et al., 2009 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
SERPINS
Members (13)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Acp76A
Accessory gland protein 76A
Spn76A, Accessory gland-specific peptide 76A
(Gubb, 2012.9.27, Reichhart et al., 2011, Garrett et al., 2009)
CG43366
(Gubb, 2012.9.27, Reichhart et al., 2011)
Spn28Db
Serpin 28Db
(Gubb, 2012.9.27, Reichhart et al., 2011, Garrett et al., 2009)
Spn31A
Serpin 31A
(Gubb, 2012.9.27, Reichhart et al., 2011, Garrett et al., 2009)
Spn43Ab
Serpin 43Ab
Serine protease inhibitor 43Ab
(Gubb, 2012.9.27, Reichhart et al., 2011, Garrett et al., 2009)
Spn43Ad
Serpin 43Ad
(Gubb, 2012.9.27, Reichhart et al., 2011, Garrett et al., 2009)
Spn47C
Serpin 47C
(Gubb, 2012.9.27, Reichhart et al., 2011, Garrett et al., 2009)
Spn53F
Serpin 53F
(Gubb, 2012.9.27, Reichhart et al., 2011, Garrett et al., 2009)
Spn75F
Serpin 75F
BG642378
(Gubb, 2012.9.27, Reichhart et al., 2011, Garrett et al., 2009)
Spn77Bb
Serpin 77Bb
(Gubb, 2012.9.27, Reichhart et al., 2011, Garrett et al., 2009)
Spn77Bc
Serpin 77Bc
(Gubb, 2012.9.27, Reichhart et al., 2011, Garrett et al., 2009)
Spn85F
Serpin 85F
(Gubb, 2012.9.27, Reichhart et al., 2011, Garrett et al., 2009)
Spn100A
Serpin 100A
(Gubb, 2012.9.27, Reichhart et al., 2011, Garrett et al., 2009)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
N-SPN
NON-INHIBITORY SERPINS
Non-inhibitory Serpins
Non-inhibitory serpin-fold
Spn
Serp
Srp
Secondary FlyBase ID(s)
References (4)