FB2024_03 , released June 25, 2024
Chemical: topotecan
Open Close
General Information
Name
topotecan
FlyBase ID
FBch0000926
ChEBI Name
topotecan
ChEBI ID
CHEBI:63632
PubChem Name
Topotecan
PubChem ID
60700 (PubChem link: Topotecan)
Chemical Structure
Chemical structure of topotecan
topotecan
InChIKey

UCFGDBYHRUNTLO-QHCPKHFHSA-N

Definition (ChEBI)

ChEBI: Topotecan is a pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. It has a role as an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an antineoplastic agent.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (22)
Synonyms
(S)-Topotecan
(PubChem, 2019-)
(s)-topotecan
(PubChem, 2019-)
123948-87-8
(PubChem, 2019-)
9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin
(ChEBI, 2019-)
Hycamptamine
(PubChem, 2019-)
Hycamtin
(PubChem, 2019-)
PubChem:60700
(PubChem, 2019-)
Topotecan
(Markstein et al., 2014)
Topotecan lactone
(PubChem, 2019-)
Topotecane
(PubChem, 2019-)
Topotecane [INN-French]
(PubChem, 2019-)
Topotecanum
(PubChem, 2019-)
Topotecanum [INN-Latin]
(PubChem, 2019-)
hycamptamine
(PubChem, 2019-)
hycamtin
(PubChem, 2019-)
pubchem:60700
(PubChem, 2019-)
topotecan
(ChEBI, 2019-, Kocak et al., 2019, PubChem, 2019-)
topotecan lactone
(PubChem, 2019-)
topotecane
(ChEBI, 2019-, PubChem, 2019-)
topotecane [inn-french]
(PubChem, 2019-)
topotecanum
(ChEBI, 2019-, PubChem, 2019-)
topotecanum [inn-latin]
(PubChem, 2019-)
Secondary FlyBase IDs
    References (4)