FB2024_03 , released June 25, 2024
Chemical: verapamil
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General Information
Name
verapamil
FlyBase ID
FBch0000313
ChEBI Name
verapamil
ChEBI ID
PubChem Name
Verapamil
PubChem ID
2520 (PubChem link: Verapamil)
Chemical Structure
Chemical structure of verapamil
verapamil
InChIKey
Definition (ChEBI)

ChEBI: 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile is a tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group. It is a tertiary amino compound, an aromatic ether, a polyether and a nitrile.NCI Thesaurus (NCIt): Verapamil is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (25)
Synonyms
Secondary FlyBase IDs
    References (9)