Frameshift deletion of bases 4:954674 through 4:954678 (R6) resulting in addition of RRLSYNKPLKYSKSCTP and premature protein truncation after these novel amino acids. Alternative transcription start sites result in the changes having different positions in different protein isoforms (for example, the novel amino acids are added after proline 562 of 4E-T protein isoforms RB, RC and RG).