Expression of RQ63E.Scer\UAS.P\T in the amnioserosa under the control of Scer\GAL4c381 results in dorsal closure defects. More than 60% of embryos have open dorsal holes at the end of stage 15 with about 20% of embryos failing to complete dorsal closure altogether. Embryos exhibit greater integrin recruitment to the lateral membrane of amnioserosa (AS) cells.