UASt regulates expression of Hsap\NRXN1 bearing the Y282H mutation (found in Autism spectrum disorder patients) with a C-terminal Tag:FLAG tag.
The expression of Hsap\NRXN1Y282H.UAS.Tag:FLAG under the control of , Scer\GAL4tim.PE or Scer\GAL4P2.4.Pdf leads to circadian defects: Scer\GAL4elav.PU-driven expression induces increased evening activity, as well as decreased total and day-time sleep time, with more but shorter total and day-time sleep bouts, and fewer but longer night-time sleep bouts; Scer\GAL4tim.PE-driven expression leads to increased circadian period and decreased rhythmicity, as well as decreased total and night-time sleep time, with fewer total and night-time sleep bouts, and increased day-time sleep time, with more sleep bouts; Scer\GAL4P2.4.Pdf-driven expression induces increased evening activity, as well as more but shorter total and day-time sleep bouts.