FB2024_03 , released June 25, 2024
Allele: Hsap\NRXN1WT.UAS.Tag:FLAG
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General Information
Symbol
Hsap\NRXN1WT.UAS.Tag:FLAG
Species
H. sapiens
Name
FlyBase ID
FBal0370775
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulates expression of full length, wild type Hsap\NRXN1 with a C-terminal Tag:FLAG tag.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of Hsap\NRXN1WT.UAS.Tag:FLAG under the control of Scer\GAL4elav.PU, Scer\GAL4tim.PE or Scer\GAL4P2.4.Pdf leads to circadian defects: Scer\GAL4tim.PE-driven expression leads to increased increased evening activity, circadian period and decreased rhythmicity, as well as more but shorter total sleep bouts, decreased day-time sleep, with more but shorter sleep bouts, and fewer night-time sleep bouts; Scer\GAL4tim.PE-driven expression leads to increased evening activity, as well as fewer but longer total sleep bouts, increased day-time sleep, with more sleep bouts, and fewer but longer night-time sleep; Scer\GAL4P2.4.Pdf-driven expression leads to increased evening activity and decreased morning index, as well as more total sleep bouts, and more but shorter day-time sleep bouts.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Hsap\NRXN1WT.UAS.Tag:FLAG
Name Synonyms
Secondary FlyBase IDs
    References (1)