FB2024_03 , released June 25, 2024
Allele: Dmel\promLΔ19
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General Information
Symbol
Dmel\promLΔ19
Species
D. melanogaster
Name
FlyBase ID
FBal0356131
Feature type
allele
Associated gene
Dmel\promL
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Ryu et al., 2019)
Mutagen
CRISPR/Cas9
(Ryu et al., 2019)
Progenitor genotype
Cytology
Description

Mutation (deletion of 19bp and insertion of 1bp) within the first exon of promL.

(Ryu et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3L:3,120,960..3,120,979 [-]
Comment:

20bp in the first coding exon of promL are deleted and replaced with a "C" leading to a net 19bp deletion and a frameshift mutation.

Inserted_sequence:

C

(Ryu et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      promLΔ19 adults survive longer (under starvation and normal feeding conditions) while they do not exhibit any significant morphological or developmental defects (such as body size and weight) when compared to controls.

      (Ryu et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      promLΔ19
      (Ryu et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)