FB2024_03 , released June 25, 2024
Allele: Dmel\AtpαLAN
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General Information
Symbol
Dmel\AtpαLAN
Species
D. melanogaster
Name
FlyBase ID
FBal0355615
Feature type
allele
Associated gene
Dmel\Atpα
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Karageorgi et al., 2019)
gene targeting by homologous recombination
(Karageorgi et al., 2019)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q?L.

(Karageorgi et al., 2019)

Knock-in at the Atpα locus carrying a single substitution equivalent to Q111L in the orthologous gene of the monarch butterfly (Danaus plexippus), as occurred in the mutational path of the monarch gene in its evolution of a specialized response to cardiac glycosides. This substitution is designated 'LAN', referring to overall Atpα genotype at three repeatedly changing amino acid sites (111, 119 and 122), where the starting genotype is 'QAN'. (Amino acid residues are numbered after the mature Sus scrofa protein, as in previous phylogenetic studies of Atp-alpha in insects.)

(Karageorgi et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Bang sensitivity does not differ in AtpαLAN homozygote adults when compared to controls.

      (Karageorgi et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AtpαLAN
      LAN
      (Karageorgi et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)