UASt regulatory sequences drive expression of Hsap\DNM1L (codon-optimized for Drosophila) that is carrying the Y691C amino acid replacement identified in whole exome sequencing of an individual with static encephalopathy and seizures.
Muscle mitochondrial morphology effects are observed upon Scer\GAL4Mef2.PU-mediated Hsap\DNM1LY691C.UAS expression in a Drp11/+ background.