FB2024_03 , released June 25, 2024
Allele: Dmel\MhcUAS.cDa
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General Information
Symbol
Dmel\MhcUAS.cDa
Species
D. melanogaster
Name
UAS construct a of Das
FlyBase ID
FBal0348136
Feature type
allele
Associated gene
Dmel\Mhc
Associated Insertion(s)
Carried in Construct
P{UAS-Mhc.D}
Key Links
Transgenic product class
cDNA
(Das et al., 2019)
wild_type
(Das et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Das et al., 2019)
wild_type
(Das et al., 2019)
Mutagen
in vitro construct
(Das et al., 2019)
Progenitor genotype
Carried in construct
P{UAS-Mhc.D}
Cytology
Description

UASt regulatory sequences drive expression of the wild-type Mhc RH59876 cDNA.

(Das et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mhc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dorsal longitudinal muscles of Mhc1/+ individuals expressing MhcUAS.cDa under the control of Scer\GAL4Mef2.PR show relatively normal muscle fibers and Z- discs, despite of a small frequency of fiber splitting. The pupal stage of these individuals takes longer than in controls. Adults show a mild reduction in climbing ability, as compared to controls.

      Dorsal longitudinal muscles of individuals expressing MhcUAS.cDa under the control of Scer\GAL4Mef2.PR do not show any obvious defect.

      (Das et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MhcUAS.cDa
      Name Synonyms
      UAS construct a of Das
      Secondary FlyBase IDs
        References (1)