FB2024_03 , released June 25, 2024
Allele: Dmel\CCHa1SK8
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General Information
Symbol
Dmel\CCHa1SK8
Species
D. melanogaster
Name
FlyBase ID
FBal0344089
Feature type
allele
Associated gene
Dmel\CCHa1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Ren et al., 2015)
Mutagen
CRISPR/Cas9
(Ren et al., 2015)
Progenitor genotype
Cytology
Description

Deletion of 13bp within CCHa1 results in a frameshift.

(Ren et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:14,093,273..14,093,285 [-]
Comment:

Deletion of 13bp within the CCHa1 coding sequence results in a frameshift and early translation termination after the addition of 11 novel amino acids.

(Ren et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CCHa1SK8 mutant adult males have significantly reduced overall locomotor activity under normal light-dark (LD) conditions, or in continuous darkness (DD), compared to controls; under LD conditions, the morning activity period is shortened and there is a significantly longer inactive period between morning and evening peaks, compared to controls; under DD conditions, there is a significant reduction in morning activity and a phase delay in the mean acrophase, compared to controls, with no significant effect on free-running period.

      (Fujiwara et al., 2018)

      CCHa1SK4/CCHa1SK8, CCHa1SK8/CCHa1SK8 and CCHa1SK8/+ animals do not exhibit any changes in pupariation time when compared to controls.

      (Ren et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CCHa1SK8
      (Kuwano et al., 2023, Fujiwara et al., 2018)
      ccha1SK8
      (Ren et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)