FlyBase Allele Report: Dmel\dsx[GAL4(DBD)::Zip-]

General Information

Symbol

Dmel\dsx^{GAL4(DBD)::Zip-}

Species

D. melanogaster

Name

FlyBase ID

FBal0344076

Feature type

allele

Associated gene

Dmel\dsx

Associated Insertion(s)

TI{GAL4(DBD)::Zip-}dsx^{GAL4(DBD)::Zip-}

Carried in Construct

Also Known As

dsx-ZpGal4DBD

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Shirangi et al., 2016)

Mutagen

CRISPR/Cas9

(Shirangi et al., 2016)

gene targeting by homologous recombination

(Shirangi et al., 2016)

Progenitor genotype

Associated Insertion(s)

TI{GAL4(DBD)::Zip-}dsx^{GAL4(DBD)::Zip-}

Cytology

Description

A GAL4(DBD)::Zip- hemidriver (component of the 'Split GAL4' system, contains the GAL4 DNA-binding domain) has been inserted at the start codon within exon 2 of dsx. This results in the hemidriver being expressed under the control of endogenous dsx sequences, along with deletion of exon 2.

(Shirangi et al., 2016)

Allele components

Component

Use(s)

Inserted element

TI{GAL4(DBD)::Zip-}

promoter trap

Encoded product / tool

GAL4(DBD)::Zip-

split driver - DNA-binding fragment

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | male limited (with dsx^{f00683-d07058})

(Shirangi et al., 2016)

Phenotype Manifest In

adult doublesex TN1A (male) neuron (with dsx^{f00683-d07058})

(Shirangi et al., 2016)

Detailed Description

Statement

Reference

dsx^{GAL4(DBD)::Zip-}/dsx^{f00683-d07058} adult males have a similar number of doublesex TN1A neurons to dsx^{GAL4(DBD)::Zip-}/+ controls; these neurons have a similar gross morphology and similar anterior arbor volume, but significantly reduced posterior arbor volume, compared to dsx^{GAL4(DBD)::Zip-}/+ controls.

(Shirangi et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions