FB2024_03 , released June 25, 2024
Allele: Dmel\MRG15Δ
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General Information
Symbol
Dmel\MRG15Δ
Species
D. melanogaster
Name
FlyBase ID
FBal0343532
Feature type
allele
Associated gene
Dmel\MRG15
Associated Insertion(s)
TI{TI}MRG15Δ
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-out gene targeting
(Schmähling et al., 2018)
Progenitor genotype
Associated Insertion(s)
TI{TI}MRG15Δ
Cytology
Description

Deletion of almost the entire MRG15 coding region (deletion corresponds to nucleotides 3R:15276676..15277889 , release 6 genome). A w+mW.hs marker replaces the deleted sequence.

(Schmähling et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:15,276,676..15,277,889 [-]
Comment:

Almost all of MRG15 is deleted ( 3R:15276676..15277889 ) and replaced with a w+mW.hs marker.

(Schmähling et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A substantial fraction of MRG15Δ/MRG15Δ animals that contain maternally deposited but lack zygotically expressed MRG15 protein eclose from the pupal case and they exhibit mild HOX loss-of-function phenotypes in the adult epidermis as their only detectable morphological defect compared to controls. Many of them die shortly after eclosion. Better survival rates are observed in MRG15Δ/Df(3R)BSC741 animals.

      Majority of MRG15Δ/Df(3R)BSC741 animals that contain maternally deposited but lack zygotically expressed MRG15 protein eclose from the pupal case and are fertile.

      MRG15Δ/Df(3R)BSC741 animals that lack both zygotically expressed and maternally deposited MRG15 protein exhibit homeotic transformations as pharate adults and majority of them fail to eclose from the pupal case compared to controls.

      (Schmähling et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      MRG15Δ
      (Schmähling et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)