Adults expressing Hsap\KCNS2^D379E.UAS under the control of Scer\GAL4^elav-C155 do not show any apparent gross morphological defect, as compared to controls. This expression throughout development and adulthood, or only during adulthood (by using Gal80[ts] for the temporal control of expression), leads to a high proportion of individuals showing an abnormal wing posture and results in increased locomotor capacity in climbing assays, as compared to controls. This expression only during adulthood, but not throughout development and adulthood, leads to a small but significant decrease in lifespan, as compared to controls.

The expression of Hsap\KCNS2^D379E.UAS under the control of either Scer\GAL4^P2.4.Pdf or Scer\GAL4^tim.PE leads to a significant decrease in night-time sleep (and concurrent significant increase in night-time activity), although it does not affect the circadian period and rhythmicity, as compared to controls. The expression of Hsap\KCNS2^D379E.UAS under the control of Scer\GAL4^P2.4.Pdf also induces an alteration in the kinetics of the Shab current in adult l-LNv neuron, namely a shift in activation to more negative voltages and a reduced Shab current after 200ms of depolarization, and induces a significant increase in the spontaneous firing rate of Shab currents in adult clock neurons, as compared to controls.