FB2024_03 , released June 25, 2024
Allele: Hsap\GCGRnSyb.Tango.QF
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General Information
Symbol
Hsap\GCGRnSyb.Tango.QF
Species
H. sapiens
Name
FlyBase ID
FBal0336698
Feature type
allele
Associated gene
Hsap\GCGR
Associated Insertion(s)
Carried in Construct
P{retro-Tango(panneuronal)}
P{trans-Tango}
P{trans-TangoMkII}
Also Known As
trans-Tango, UAS-trans-Tango
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Talay et al., 2017)
Progenitor genotype
Carried in construct
P{retro-Tango(panneuronal)}
P{trans-Tango}
P{trans-TangoMkII}
Cytology
Description

The nSyb promoter drives expression of a fusion protein that consists of the Hsap\GCGR gene fused via a Tag:CS(TEVp) cleavage site to the QF transcriptional activator. The presence of Hsap\GCGR tethers the fusion protein to the cell membrane. The QF driver can be released from the membrane by cleavage of the Tag:CS(TEVp) site with the TEVp protease.

(Talay et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
nSyb
Encoded product / tool
QF
Tagged with
Tag:CS(TEVp)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (10)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\GCGRnSyb.Tango.QF
      nSyb-DSCP-hGCGR::TEVcs::QF-hsp70pA
      (Talay et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (16)